Oxypurinol limits myocardial stunning but does not reduce infarct size after reperfusion.

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

1982 • 2,825 citations

Early phase acute myocardial infarct size quantification: Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique

1981 • 925 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

An approach to free radicals in medicine and biology.

1980 • 548 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

The Biology and Pathology of Oxygen Radicals

1978 • 437 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models.

1985 • 359 citations

Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs

1981 • 359 citations

Depression of regional blood flow and wall thickening after brief coronary occlusions

1978 • 305 citations

Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction.

1983 • 231 citations

Enzymatic and Metabolic Studies with Allopurinol

1966 • 186 citations

Involvement of hydrogen peroxide and hydroxyl radical in the ‘oxygen paradox’: Reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase**

1985 • 168 citations

Response of large and small coronary arteries to nitroglycerin, NaNO 2 , and adenosine

1972 • 164 citations

Prognostic value of exercise electrocardiogram in men at high risk of future coronary heart disease: Multiple risk factor intervention trial experience

1986 • 144 citations

Prevention of free radical-induced myocardial reperfusion injury with allopurinol

1985 • 122 citations

N-2-Mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia

1986 • 115 citations

Inhibition of urate production by allopurinol

1977 • 106 citations

Superoxide dismutase enhances recovery following myocardial ischemia

1985 • 98 citations

The effect of allopurinol on the degree of early myocardial ischemia

1980 • 64 citations

Xanthine oxidase: An enzyme playing a role in the killing mechanism of polymorphonuclear leucocytes

1980 • 33 citations

Effect of allopurinol on neutrophil superoxide production, chemotaxis, or degranulation

1985 • 29 citations

Modulation of macrophage superoxide release by purine metabolism

1983 • 27 citations

Reduction oftheExtent ofIschemic Myocardial Injury byNeutrophil Depletion intheDog

1983 • 16 citations

Effects of allopurinol on purine metabolism in cultured heart cells

1978 • 8 citations

Deleted Work

1955 • 0 citations