Oxygen free radicals play a role in cellular differentiation: An hypothesis

On the Origin of Cancer Cells

1956 • 12,141 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds

1979 • 595 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

An introduction to embryology

1965 • 429 citations

Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.

1981 • 361 citations

Functions of Glutathione in Liver and Kidney

1978 • 352 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Free radicals in molecular biology, aging, and disease

1985 • 271 citations

A mechanism of paraquat toxicity in mice and rats

1976 • 253 citations

Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues

1975 • 250 citations

Altered thiol and calcium homeostasis in oxidative hepatocellular injury

1985 • 249 citations

Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture.

1972 • 227 citations

[Origin of cancer cells].

1956 • 186 citations

The control of muscle and cartilage development in the chick limb: the role of differential vascularization

1973 • 176 citations

ÜBER DIE DETERMINATION DES KEIMES BEI ECHINODERMEN

1928 • 170 citations

Transplantation of Pluripotential Nuclei from Triploid Frog Tumors

1969 • 160 citations

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

1982 • 159 citations

Relationship between oxygen metabolism, aging and development

1986 • 151 citations

Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain

1982 • 147 citations

An Introduction to Embryology

1961 • 142 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 141 citations

Osteogenesis in cultures of limb mesenchymal cells

1979 • 136 citations

Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

1985 • 127 citations

Cell differentation, aging and cancer: The possible roles of superoxide and superoxide dismutases

1980 • 126 citations

Is an early calcium flux necessary to stimulate lymphocytes?

1977 • 122 citations

Effects of thyroxine and low oxygen tension on chondrogenic expression in cell culture

1969 • 106 citations

Differential induction of glucose‐regulated and heat shock proteins: Effects of pH and sulfhydryl‐reducing agents on chicken embryo cells

1985 • 104 citations

Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria

1979 • 102 citations

Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.

1980 • 101 citations

The effect of changes in the respiratory metabolism upon genome activity in Drosophila

1972 • 88 citations

Plasmabau und Determination bei dem Ei von Paracentrotus lividus Lk

1928 • 84 citations

DNA supercoiling affects in vitro transcription of two maize chloroplast genes differently.

1985 • 79 citations

The role of superoxide dismutase and gene amplification in carcinogenesis

1984 • 76 citations

Molecular biology of aging

1985 • 73 citations

Lipid peroxide formation in regenerating rat liver

1956 • 72 citations

Senescence and Rejuvenescence.

1915 • 71 citations

Fatty Acid Paradoxes in the Control of Cell Proliferation: Prostaglandins, Lipid Peroxides, and Cooxidation Reactions

1984 • 67 citations

Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells.

1982 • 65 citations

Commitment: How do cells make the decision to differentiate?

1981 • 65 citations

Physiological dominance and physiological isolation in development and reconstitution

1929 • 64 citations

Correlation of malignancy with the intracellular Na+:K+ ratio in human thyroid tumors.

1983 • 64 citations

Superoxide dismutase content and microsomal lipid composition of tumours with different growth rates

1980 • 64 citations

Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione: possible chemotherapeutic implications.

1979 • 64 citations

Alterations in superoxide dismutase, glutathione, and peroxides in the plasmodial slime mold Physarum polycephalum during differentiation

1985 • 52 citations

Superoxide dismutase activity in dauerlarvae of Caenorhabditis elegans (Nematoda: Rhabditidae)

1982 • 52 citations

The effect of glutathione on development in wild carrot suspension cultures

1985 • 51 citations

Variation of superoxide dismutases during the development of the fruit fly Ceratitis capitata L

1976 • 49 citations

Packaged DNA

1985 • 49 citations

Localization of the Globin Gene in the Template Active Fraction of Chromatin of Friend Leukemia Cells

1977 • 46 citations

Inhibition of cell division by ultraviolet irradiated unsaturated fatty acid*1

1957 • 42 citations

Ionic regulation in genetic translation systems.

1977 • 39 citations

Catalase is Induced by Ecdysterone and Ethanol in Drosophila Cells

1982 • 38 citations

A unifying biochemical theory of cancer, senescence and maximal life span

1977 • 37 citations

Intervening DNA insertions and the alteration of gene expression by carcinogens.

1980 • 36 citations

Superoxide dismutase in normal and malignant tissues in different species

1979 • 32 citations

Glutathione content of human skin carcinomas

1976 • 32 citations

Reversal by L-cysteine of the growth inhibitory and glutathione-depleting effects of N-methylformamide and N,N-dimethylformamide

1984 • 28 citations

Effects of the Free Radical Generator Paraquat On Differentiation, Superoxide Dismutase, Glutathione and Inorganic Peroxides In Microplasmodia of Physarum Polycephalum

1985 • 27 citations

Effects of 2,4-dinitrophenol and dinactin on heat-sensitive and ecdysone-specific puffs of Drosophila salivary gland chromosomes in vitro

1973 • 26 citations

Effect of oxygen on morphogenesis and polypeptide expression by Mucor racemosus

1985 • 25 citations

Involvement of Glutathione in the Differentiation of the Slime Mold Physarum polycephalum

1985 • 23 citations

The Diptera as a Model System in Cell and Molecular Biology

1981 • 21 citations

Role of Glutathione in the Aging and Development of Insects

1986 • 21 citations

The effects of sodium and magnesium-ion interactions on chromatin structure and solubility.

1985 • 19 citations

Developmental biology

1980 • 19 citations

Superoxide dismutase in Didymium iridis: Characterization and changes in activity during senescence and sporulation

1981 • 19 citations

Effect of Oxidation of Glutathione and Membrane Thiol Groups on Mitochondrial Functions

1978 • 15 citations

Differentiation of Mouse Neuroblastoma Cells under Increased Oxygen Tension

1980 • 9 citations

Blue light influences gene expression and motility in starving microplasmodia of Physarum polycephalum.

1982 • 9 citations

Induction of cytodifferentiation in C3H/10T mouse embryo cells by X-irradiation and benzo(a)pyrene

1985 • 7 citations

Developmental inhibition in Drosophila using dihydroxybenzoic acid isomers

1969 • 4 citations