The nicotinic acetylcholine receptor: Molecular architecture of a ligand-regulated ion channel

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Ion Channel Reconstitution

1986 • 605 citations

Electrophysiological studies of NMDA receptors

1987 • 483 citations

High frequencies of α-thalassaemia are the result of natural selection by malaria

1986 • 416 citations

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization

1986 • 414 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system

1987 • 393 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

The Cell surface and neuronal function

1980 • 379 citations

Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein

1984 • 373 citations

Expression of functional acetylcholine receptor from cloned cDNAs

1984 • 366 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

A structural model of the acetylcholine receptor channel based on partition energy and helix packing calculations

1984 • 260 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Chapter 4 Coexistence of neuronal messengers — an overview

1986 • 223 citations

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata.

1987 • 195 citations

Acetylcholine Receptor Structure, Function, and Evolution

1985 • 165 citations

Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila

1986 • 139 citations

Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata.

1974 • 108 citations

Chromosomal Localization of Muscle Nicotinic Acetylcholine Receptor Genes in the Mouse

1986 • 95 citations

Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations

1987 • 95 citations

Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics.

1986 • 83 citations

Transmembrane topology of acetylcholine receptor subunits probed with photoreactive phospholipids

1985 • 81 citations

Interaction of noncompetitive inhibitors with the acetylcholine receptor. The site specificity and spectroscopic properties of ethidium binding.

1987 • 60 citations

Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

1986 • 56 citations

Lophotoxin irreversibly inactivates the nicotinic acetylcholine receptor by preferential association at one of the two primary agonist sites.

1984 • 52 citations

Time-resolved photolabeling by quinacrine azide of a noncompetitive inhibitor site of the nicotinic acetylcholine receptor in a transient, agonist-induced state.

1985 • 51 citations

Multiple actions of substance P that regulate the functional properties of acetylcholine receptors of clonal rat PC12 cells.

1987 • 50 citations

Lipid-dependent recovery of alpha-bungarotoxin and monoclonal antibody binding to the purified alpha-subunit from Torpedo marmorata acetylcholine receptor. Enhancement by noncompetitive channel blockers.

1984 • 48 citations

Probing nicotinic acetylcholine receptors with monoclonal antibodies

1986 • 43 citations

A photoaffinity ligand of the acetylcholine‐binding site predominantly labels the region 179–207 of the α‐subunit on native acetylcholine receptor from Torpedo marmorata

1986 • 41 citations

Acetylcholine receptor: characterization of the voltage-dependent regulatory (inhibitory) site for acetylcholine in membrane vesicles from Torpedo californica electroplax

1986 • 31 citations

Thoeretical study of the packing of α-helices of poly(l-alanine) into transmembrane bundles. Possible significance for ion-transfer

1986 • 30 citations

Acetylcholine receptor dimers are stabilized by extracellular disulfide bonding

1986 • 19 citations