Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER

1991 • 318 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.

1994 • 274 citations

Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates

1981 • 262 citations

Mutation assay at the thymidine kinase locus in diploid human lymphoblasts

1982 • 245 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.

1984 • 205 citations

Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines.

1995 • 200 citations

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

1990 • 179 citations

Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

1986 • 150 citations

Absence of Radiation-induced G1 Arrest in Two Closely Related Human Lymphoblast Cell Lines That Differ in p53 Status

1995 • 136 citations

Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.

1995 • 125 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes

1993 • 117 citations

p53 abnormalities and genomic instability in primary human breast carcinomas.

1995 • 108 citations

A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus

1989 • 96 citations

Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor

1993 • 93 citations

Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen

1988 • 92 citations

p53 deficiency does not affect the accumulation of point mutations in a transgene target.

1995 • 83 citations

Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells

1990 • 83 citations

Different Capacities for Recombination in Closely Related Human Lymphoblastoid Cell Lines with Different Mutational Responses to X-Irradiation

1994 • 82 citations

Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro

1992 • 71 citations

The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status

1995 • 65 citations

Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation.

1994 • 58 citations

Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein.

1995 • 55 citations

Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis

1995 • 44 citations

A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants

1992 • 36 citations

A comparison of induced mutation at homologous alleles of the tk locus in human cells

1991 • 36 citations

Recombinagenic activity of the phorbol ester 12-O-Metradecanoylphorbol-13-acetate in human lymphoblastoid cells

1995 • 17 citations

Demonstration by DNA fingerprint analysis of genomic instability in mouse BALB 3T3 cells during cell transformation

1994 • 11 citations