Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

1985 • 555 citations

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour

1984 • 538 citations

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours

1984 • 426 citations

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition.

1985 • 415 citations

Development of homozygosity for chromosome 11p markers in Wilms' tumour

1984 • 411 citations

Loss of a Harvey ras allele in sporadic Wilms' tumour

1984 • 336 citations

Human lymphoblastoid lines from lymph node and spleen

1968 • 261 citations

Mutation assay at the thymidine kinase locus in diploid human lymphoblasts

1982 • 245 citations

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

1978 • 206 citations

Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.

1984 • 205 citations

Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/− mouse lymphoma cells

1985 • 158 citations

Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

1986 • 150 citations

Deletion and amplification of the HGPRT locus in Chinese hamster cells.

1983 • 147 citations

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations

1985 • 146 citations

Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes

1985 • 143 citations

A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.

1984 • 122 citations

Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions.

1986 • 122 citations

Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.

1986 • 106 citations

Chromosome 11 aberrations in small colony L5178Y TKPsu−/− mutants early in their clonal history

1985 • 103 citations

The molecular nature of mutations in cultured mammalian cells: A review

1985 • 95 citations

Structure of mutant alleles at the aprt locus of Chinese hamster ovary cells

1983 • 94 citations

Recessive mutant genes predisposing to human cancer.

1986 • 93 citations

High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous foraprt

1982 • 87 citations

Mutation and growth rates from Luria-Delbrück fluctuation tests

1982 • 84 citations

In situ analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/− mouse lymphoma cells

1985 • 77 citations

SOUTHERN ANALYSIS OF GENOMIC ALTERATIONS IN GAMMA-RAY-INDUCED APRT- HAMSTER CELL MUTANTS

1986 • 77 citations

Chemically induced aneuploidy in mammalian cells in culture

1986 • 66 citations

Mutations in human lymphocytes commonly involve gene duplication and resemble those seen in cancer cels.

1988 • 62 citations

High-frequency structural gene deletion as the basis for functional hemizygosity of the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells.

1983 • 56 citations

Loss of alleles at polymorphic loci on chromosome 2 in uveal melanoma

1986 • 55 citations

The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK−/−) mutants from L5178Y/TK+/− mouse lymphoma cells

1981 • 54 citations

Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.

1987 • 53 citations

High-frequency mutation at the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells due to deletion of the gene.

1983 • 52 citations

Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture.

1982 • 45 citations

Alterations of Gene Structure in Ethyl Methane Sulfonate-Induced Mutants of Mammalian Cells

1982 • 41 citations

Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.

1988 • 40 citations

The aprt heterozygote/hemizygote system for screening mutagenic agents allows detection of large deletions

1988 • 36 citations

Localization of the oncogene c‐erbA1 immediately proximal to the acute promyelocytic leukaemia breakpoint on chromosome 17

1985 • 36 citations

Mechanism of mutation at the aprt locus in Chinese hamster ovary cells: analysis of heterozygotes and hemizygotes.

1983 • 34 citations

High frequency ?switching? at the adenine phosphoribosyltransferase locus in multipotent mouse teratocarcinoma stem cells

1984 • 32 citations

Chromosome 14 marker appearance in a human B lymphoblastoid cell line of nonmalignant origin

1986 • 32 citations

Structural alterations of the aprt locus induced by deoxyribonucleoside triphosphate pool imbalances in Chinese hamster ovary cells.

1984 • 29 citations

Expression of recessiveAprt ? mutations in mouse CAK cells resulting from chromosome loss and duplication

1983 • 27 citations

DNA methylation and genetic inactivation at thymidine kinase locus: Two different mechanisms for silencing autosomal genes

1988 • 26 citations

Amplification versus mutation as a mechanism for reversion of anHGPRT mutation

1984 • 25 citations

Persistence of X-ray-induced chromosomal rearrangements in long-term cultures of human diploid fibroblasts.

1984 • 24 citations

High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to Subband 17q11.2

1986 • 19 citations

Germ-line chromosomal localization of humanc-erb-A oncogene

1985 • 12 citations

Mutation assay in diploid human lymphoblasts: methodological aspects.

1977 • 6 citations