HLA-E is expressed on trophoblast and interacts with CD94 / NKG2 receptors on decidual NK cells

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

1998 • 998 citations

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

1997 • 933 citations

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

1998 • 719 citations

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis

1998 • 706 citations

Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40

2000 • 641 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

HLA-E Surface Expression Depends on Binding of TAP-Dependent Peptides Derived from Certain HLA Class I Signal Sequences

1998 • 495 citations

The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9

1997 • 489 citations

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

1990 • 388 citations

HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

1998 • 366 citations

The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells

1999 • 355 citations

Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E

1999 • 355 citations

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

1997 • 327 citations

Human implantation : cell biology and immunology

1995 • 298 citations

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

1998 • 275 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

On the nature and function of human uterine granular lymphocytes

1991 • 267 citations

Evidence for the expression of HLAA-C class I mRNA and protein by human first trimester trophoblast.

1996 • 259 citations

Tetrameric Complexes of Human Histocompatibility Leukocyte Antigen (HLA)-G Bind to Peripheral Blood Myelomonocytic Cells

1999 • 252 citations

Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast

1989 • 233 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Screening for cytokine messenger ribonucleic acids in purified human decidual lymphocyte populations by the reverse-transcriptase polymerase chain reaction.

1994 • 207 citations

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

1998 • 198 citations

Expression of killer cell inhibitory receptors on human uterine natural killer cells

1997 • 187 citations

CD94 and a Novel Associated Protein (94AP) Form a NK Cell Receptor Involved in the Recognition of HLA-A, HLA-B, and HLA-C Allotypes

1996 • 187 citations

Human trophoblast and JEG choriocarcinoma cells are sensitive to lysis by IL-2-stimulated decidual NK cells

1990 • 174 citations

Specific Recognition of HLA-E, But Not Classical, HLA Class I Molecules by Soluble CD94/NKG2A and NK Cells

1999 • 172 citations

Evaluation of trophoblast HLA‐G antigen with a specific monoclonal antibody

1997 • 146 citations

Why certain antibodies cross-react with HLA- A and HLA-G: Epitope mapping of two common MHC class I reagentsfn2fn2This work was supported by a grant from the National Institutes of Health (R01AI38577-01) and by a Reproductive Scientist Development Award, the Society for Gynecologic Investigation, and National Institutes of Health Grant K12HD00849 (to D.J.S.)

1998 • 126 citations

Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen.

1995 • 124 citations

The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1+ NK cell clones

1999 • 113 citations

Trophoblast Cell Line Resistance to NK Lysis Mainly Involves an HLA Class I-Independent Mechanism

1999 • 97 citations

Expression of HLA class I molecules in human first trimester and term placenta trophoblast

1996 • 93 citations

Human uterine NK cells have a similar repertoire of killer inhibitory and activatory receptors to those found in blood, as demonstrated by RT-PCR and sequencing

1997 • 89 citations

Methylation status and transcriptional expression of the MHC class I loci in human trophoblast cells from term placenta.

1995 • 83 citations

Screening for cytokine mRNA in human villous and extravillous trophoblasts using the reverse-transcriptase polymerase chain reaction (RT-PCR)

1995 • 81 citations

The HLA-E gene encodes two differentially regulated transcripts and a cell surface protein.

1992 • 81 citations

Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells

1996 • 77 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody.

1991 • 61 citations

Immunological aspects of human implantation.

2000 • 55 citations

Human Lymphocytes Obtained from Decidual Tissue Express Killer Activatory Receptors as Well as Killer Inhibitory Receptors: Analysis Using a Single Strand Conformation Polymorphism Method

1998 • 5 citations