Trophoblast Cell Line Resistance to NK Lysis Mainly Involves an HLA Class I-Independent Mechanism

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

1990 • 1,417 citations

HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

1998 • 998 citations

RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

1996 • 871 citations

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis

1998 • 706 citations

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

1997 • 691 citations

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells

1996 • 489 citations

Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.

1995 • 479 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

NK susceptibility varies inversely with target cell class I HLA antigen expression.

1987 • 433 citations

Isolation of Hormone-Producing Clonal Lines of Human Choriocarcinoma¹

1971 • 384 citations

The α₁domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: Is HLA-G the public ligand for natural killer cell inhibitory receptors?

1997 • 354 citations

Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle

1989 • 314 citations

Cell populations in human early pregnancy decidua: characterization and isolation of large granular lymphocytes by flow cytometry.

1988 • 284 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

On the nature and function of human uterine granular lymphocytes

1991 • 267 citations

Evidence for the expression of HLAA-C class I mRNA and protein by human first trimester trophoblast.

1996 • 259 citations

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor

1997 • 252 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.

1994 • 193 citations

Resistance of HLA-G and HLA-A2 Transfectants to Lysis by Decidual NK Cells

1994 • 179 citations

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.

1993 • 178 citations

The JAr cell line - continuous human multi-hormone production and controls

1971 • 175 citations

Human trophoblast and JEG choriocarcinoma cells are sensitive to lysis by IL-2-stimulated decidual NK cells

1990 • 174 citations

The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.

1997 • 159 citations

Follow the Leader: NK Cell Receptors for Classical and Nonclassical MHC Class I

1998 • 156 citations

Evaluation of trophoblast HLA‐G antigen with a specific monoclonal antibody

1997 • 146 citations

Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6.

1986 • 141 citations

CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.

1997 • 140 citations

Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells

1997 • 139 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody.

1990 • 136 citations

A simple method to eliminate the antigenicity of surface class I MHC molecules from the membrane of viable cells by acid treatment at pH 3

1987 • 133 citations

Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell‐mediated lysis is inversely correlated with HLA class I antigen expression

1989 • 133 citations

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies

1996 • 133 citations

Why certain antibodies cross-react with HLA- A and HLA-G: Epitope mapping of two common MHC class I reagentsfn2fn2This work was supported by a grant from the National Institutes of Health (R01AI38577-01) and by a Reproductive Scientist Development Award, the Society for Gynecologic Investigation, and National Institutes of Health Grant K12HD00849 (to D.J.S.)

1998 • 126 citations

Increased resistance to non-MHC-restricted cytotoxicity related to HLA A, B expression. Direct demonstration using beta 2-microglobulin-transfected Daudi cells.

1988 • 106 citations

Phenotypic and functional cellular differences between human CD3- decidual and peripheral blood leukocytes.

1994 • 103 citations

HLA‐G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex

1997 • 90 citations

Cytotoxic activity against trophoblast and choriocarcinoma cells of large granular lymphocytes from human early pregnancy decidua

1991 • 84 citations

Methylation status and transcriptional expression of the MHC class I loci in human trophoblast cells from term placenta.

1995 • 83 citations

Susceptibility to Natural Killer Cell-Mediated Cytolysis Is Independent of the Level of Target Cell Class I HLA-A Expression1

2015 • 66 citations

HLA-E is the only class I gene that escapes CpG methylation and is transcriptionally active in the trophoblast-derived human cell line JAR

1993 • 64 citations

H-2 antigen expression and sensitivity of BL6 melanoma cells to natural killer cell cytotoxicity.

1988 • 60 citations

H-2Kb antigen expression has no effect on natural killer susceptibility and tumorigenicity of a murine hepatoma.

1988 • 52 citations

Lysis of a lung carcinoma by poly I:C-induced natural killer cells is independent of the expression of class I histocompatibility antigens.

1988 • 50 citations

Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression.

1989 • 49 citations

Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells

1990 • 46 citations

Target cell expression of MHC antigens is not (always) a turn-off signal to natural killer cells.

1988 • 46 citations

Decidual cellular responses

1989 • 46 citations

Compared TCR and CD3 epsilon expression on alpha beta and gamma delta T cells. Evidence for the association of two TCR heterodimers with three CD3 epsilon chains in the TCR/CD3 complex.

1995 • 44 citations

Human trophoblast cell resistance to decidual NK lysis is due to lack of NK target structure

1990 • 43 citations

Antigen processing and presentation by human trophoblast-derived cell lines.

1997 • 42 citations

Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells.

1989 • 40 citations

Immunology: Keeping mother at bay

1996 • 34 citations

Effect of IFN-γ and IFN-α on killing of human trophoblast by decidual LAK cells

1993 • 33 citations

Evidence for the expression of HLA-C class I mRNA and protein by human first trimester trophoblast

1996 • 24 citations

Transfected trophoblast‐derived human cells can express a single HLA class I allelic product

1991 • 16 citations

Adhesive Properties of Choriocarcinoma Cells toward Lymphocytes Activated or Not by Interleukin-2

1994 • 14 citations