A Novel Mutant Topoisomerase II.alpha. Present in VP-16-Resistant Human Melanoma Cell Lines Has a Deletion of Alanine 429

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1987 • 691 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

1981 • 361 citations

DNA Topoisomerase II Must Act at Mitosis To Prevent Nondisjunction and Chromosome Breakage

1989 • 302 citations

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

1987 • 282 citations

Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli

1986 • 281 citations

Biochemical basis for the interactions of type I and type II topoisomerases with DNA

1989 • 251 citations

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

1989 • 250 citations

Catalytic function of DNA topoisomerase II

1991 • 246 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?

1990 • 236 citations

Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

1986 • 231 citations

Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro.

1985 • 214 citations

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene

1984 • 175 citations

Segregation of recombined chromosomes in meiosis I requires DNA topoisomerase II

1990 • 172 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

1992 • 166 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein.

1979 • 158 citations

DNA sequence of theE. coli gyrB gene: application of a new sequencing strategy

1987 • 158 citations

Structure of the Drosophila DNA topoisomerase II gene

1989 • 153 citations

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

1991 • 149 citations

Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.

1991 • 146 citations

A topoisomerase from Escherichia coli related to DNA gyrase.

1979 • 141 citations

Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation).

1985 • 126 citations

Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding.

1991 • 124 citations

Unknotting the Complexities of Multidrug Resistance: The Involvement of DNA Topoisomerases in Drug Action and Resistance

1989 • 107 citations

Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide.

1992 • 95 citations

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1992 • 94 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA

1990 • 84 citations

A Functional 125-kDa Core Polypeptide of Fission Yeast DNA Topoisomerase II

1991 • 71 citations

Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.

1993 • 68 citations

Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino) methane-sulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase ii in a murine mastocytoma cell line

1989 • 53 citations

The role of topoisomerase II in drug resistance

1991 • 41 citations

Abrogation of etoposide-mediated cytotoxicity by cycloheximide

1988 • 40 citations

Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II

1993 • 20 citations

Linker Insertion Mutagenesis Of Drosophila Topoisomerase II

1994 • 20 citations

Mechanisms of the in vivo resistance to adriamycin and modulation by calcium channel blockers in mice.

1989 • 20 citations

Evidence that a protein kinase enhances amsacrine mediated formation of topoisomerase II-DNA complexes in murine mastocytoma cell nuclei

1991 • 15 citations

A protein factor that enhances amsacrine-mediated formation of topoisomerase II-DNA complexes in murine mastocytoma cell nuclei

1989 • 12 citations