Genetic, Biochemical, and Transcriptional Responses of Saccharomyces cerevisiae to the Novel Immunomodulator FTY720 Largely Mimic Those of the Natural Sphingolipid Phytosphingosine

Methods in yeast genetics

1979 • 7,824 citations

Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes

2000 • 4,803 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae

1994 • 2,554 citations

The economics of ribosome biosynthesis in yeast

1999 • 1,869 citations

Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

1999 • 1,793 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Nitrogen regulation in Saccharomyces cerevisiae

2002 • 612 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast

2000 • 550 citations

Lipid-dependent Targeting of G Proteins into Rafts

2000 • 428 citations

Sphingolipid Synthesis as a Target for Antifungal Drugs

1997 • 396 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual

1998 • 287 citations

Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants

2000 • 279 citations

SPHINGOLIPID FUNCTIONS INSACCHAROMYCES CEREVISIAE: Comparison to Mammals

1998 • 257 citations

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

2000 • 241 citations

Sphingolipid functions in Saccharomyces cerevisiae

2002 • 237 citations

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

1994 • 210 citations

Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.

1992 • 187 citations

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

1998 • 184 citations

N,N-Dimethylsphingosine Inhibition of Sphingosine Kinase and Sphingosine 1-Phosphate Activity in Human Platelets

1996 • 162 citations

Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.

1993 • 132 citations

Sphingolipids Signal Heat Stress-induced Ubiquitin-dependent Proteolysis

2000 • 112 citations

Accumulation of Phosphorylated Sphingoid Long Chain Bases Results in Cell Growth Inhibition in Saccharomyces cerevisiae

2000 • 107 citations

Phytosphingosine as a Specific Inhibitor of Growth and Nutrient Import in Saccharomyces cerevisiae

2001 • 101 citations

The identification of myriocin-binding proteins

1999 • 94 citations

Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids

1997 • 93 citations

Inhibition of Amino Acid Transport by Sphingoid Long Chain Bases in Saccharomyces cerevisiae

1998 • 80 citations

Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells

2001 • 58 citations

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor

2002 • 56 citations

Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined through Gene Expression Profiling

2003 • 54 citations

Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats

1996 • 48 citations

FTY720: a new immunosuppressive agent with novel mechanism(s) of action

1998 • 39 citations

Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase

1995 • 37 citations

The Sge1 protein ofSaccharomyces cerevisiae is a membrane-associated multidrug transporter

1998 • 32 citations

A novel Rtg2p activity regulates nitrogen catabolism in yeast

2001 • 25 citations

Ubiquitin Pathway Proteins Influence the Mechanism of Action of the Novel Immunosuppressive Drug FTY720 in Saccharomyces cerevisiae

2003 • 24 citations

Carnitine Uptake by AGP2 in Yeast Saccharomyces cerevisiae Is Dependent on Hog1 MAP Kinase Pathway

2002 • 23 citations

Immunosuppressant-like effects of phenylbutyrate on growth inhibition of Saccharomyces cerevisiae

2002 • 11 citations