2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Lasting Remissions in Hairy-Cell Leukemia Induced by a Single Infusion of 2-Chlorodeoxyadenosine

1990 • 521 citations

Fludarabine: a new agent with major activity against chronic lymphocytic leukemia

1989 • 466 citations

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the national cancer institute‐sponsored working group

1988 • 415 citations

Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

1985 • 397 citations

Tight-binding inhibitors—IV. Inhibition of adenosine deaminases by various inhibitors

1977 • 376 citations

Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes

1983 • 271 citations

Fludarabine: a new agent with major activity against chronic lymphocytic leukemia

1989 • 260 citations

2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia

1988 • 237 citations

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

1980 • 224 citations

2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia

1988 • 176 citations

Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.

1984 • 160 citations

The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts.

1981 • 144 citations

Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy.

1990 • 125 citations

2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T- cell lymphoma

1992 • 102 citations

Immunosuppressive effects of pentostatin.

1990 • 99 citations

Efficacy of 2'-Deoxycoformycin in Hairy-Cell Leukemia: A Study of the National Cancer Institute of Canada Clinical Trials Group1

1988 • 91 citations

Purine nucleoside metabolism in the erythrocytes of patients with adenosine deaminase deficiency and severe combined immunodeficiency.

1976 • 84 citations

Fludarabine therapy in hairy cell leukemia

1991 • 59 citations

Durable complete remissions after 2′‐deoxycoformycin treatment in patients with hairy cell leukemia resistant to interferon alpha

1990 • 28 citations

Vomiting associated with pentostatin and pentostatin plus alpha-interferon: Unique pattern and potential mechanisms

1990 • 5 citations

Repeated pentostatin (2'deoxycoformycin)-induced remissions in a patient with advanced chronic lymphocytic leukemia.

1988 • 5 citations

Rapid response to 2′‐deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma

1988 • 4 citations

The treatment of hairy cell leukemia with 2'-deoxycoformycin: results in India and in the United States.

1987 • 3 citations