Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Isolation of Lymphocytes, Granulocytes and Macrophages

1976 • 1,621 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

Corticosteroids and Lymphoid Cells

1972 • 1,030 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

1980 • 488 citations

Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation.

1981 • 448 citations

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

An improved cycling assay for nicotinamide adenine dinucleotide

1973 • 382 citations

Regulation of DNA ligase activity by poly(ADP-ribose)

1982 • 369 citations

ENZYMATIC SYNTHESIS OF TRIPHOSPHOPYRIDINE NUCLEOTIDE

1950 • 338 citations

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

1978 • 277 citations

The Involvement of Poly(ADP‐ribose) Polymerase in the Degradation of NAD Caused by γ‐Radiation and N‐Methyl‐N‐Nitrosourea

1979 • 275 citations

Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes

1983 • 271 citations

The Rate of Strand Separation in Alkali of DNA of Irradiated Mammalian Cells

1975 • 248 citations

Biochemistry of Diseases of Immunodevelopment

1981 • 242 citations

Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease

1978 • 230 citations

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

1980 • 224 citations

Association of Poly(Adenosine Diphosphoribose) Synthesis with DNA Damage and Repair in Normal Human Lymphocytes

1979 • 222 citations

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

1978 • 209 citations

Pyridine nucleotide levels as a function of growth in normal and transformed 3T3 cells

1976 • 200 citations

Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.

1978 • 200 citations

The Rate of Strand Separation in Alkali of DNA of Irradiated Mammalian Cells

2012 • 197 citations

Poly(adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled DNA synthesis in normal human lymphocytes

1982 • 181 citations

Differential Sensitivity of Human Leukemic T Cell Lines and B Cell Lines to Growth Inhibition by Deoxyadenosine

1978 • 167 citations

Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.

1984 • 160 citations

The inhibition of carbohydrate metabolism in ascites-tumour cells by ethyleneimines

1956 • 128 citations

Native and denatured DNA, cross-linked and palindromic DNA and circular covalently-closed DNA analysed by a sensitive fluorometric procedure

1974 • 125 citations

Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells.

1982 • 123 citations

ATP depletion as a consequence of adenosine deaminase inhibition in man.

1980 • 108 citations

The deoxyribonucleoside 5′-triphosphate (dATP and dTTP) pool in phytohemagglutinin-stimulated and non-stimulated human lymphocytes

1973 • 90 citations

Nicotinamide stimulates repair of DNA damage in human lymphocytes

1980 • 86 citations

Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes.

1980 • 74 citations

Purine deoxynucleoside toxicity in nondividing human lymphoid cells.

1982 • 71 citations

Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase.

1982 • 70 citations

DNA strand breaks induced in human T-lymphocytes by the combination of deoxyadenosine and deoxycoformycin.

1984 • 70 citations

Survival of Human T and B Lymphocytes after X-irradiation

1976 • 66 citations

Radiosensitivity of Human Lymphocytes and Thymocytes

1977 • 64 citations

Deoxycoformycin-induced response in chronic lymphocytic leukaemia: deoxyadenosine toxicity in non-replicating lymphocytes

1982 • 59 citations

Ultraviolet-induced DNA excision repair in human B and T lymphocytes II. Effect of inhibitors and DNA precursors

1979 • 55 citations

Inhibition of RNA synthesis by deoxyadenosine plus deoxycoformycin in resting lymphocytes.

1983 • 48 citations

ADP-ribosylation of isolated nuclei from HeLa cells, rat liver, fetal rat liver, and Novikoff hepatoma. Effect of nicotinamide adenine dinucleotide analogs on template activity for DNA synthesis, incorporation into nuclear proteins, and a new 1''-3' osidic linkage.

1977 • 45 citations

Pyridine nucleotide metabolism in mammalian cells in culture

1973 • 42 citations

DNA strand breaks in murine lymphocytes: Induction by purine and pyrimidine analogues

1983 • 36 citations

Poly (ADP-Ribose) and ADP-Ribosylation of Proteins

1977 • 25 citations

The pathway of biosynthesis of nicotinamide–adenine dinucleotide in rat mammary gland

1968 • 24 citations

Adenosine diphosphate ribosylation of histone and nonhistone chromosomal proteins with oxidized nicotinamide adenine dinucleotide and 2'-deoxynicotinamide adenine dinucleotide using nuclei isolated from rat liver and HeLa cells

1979 • 19 citations

Genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase and their implications for therapy of leukemias.

1983 • 12 citations

Kinetic Aspects of Soluble Dehydrogenases Requiring Nicotinamide Coenzymes

1980 • 6 citations