Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1977 • 416 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

1978 • 277 citations

Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes

1983 • 271 citations

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

1980 • 224 citations

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

1978 • 209 citations

The biochemical and clinical consequences of 2'-deoxycoformycin in refractory lymphoproliferative malignancy

1981 • 199 citations

Differential Sensitivity of Human Leukemic T Cell Lines and B Cell Lines to Growth Inhibition by Deoxyadenosine

1978 • 167 citations

The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts.

1981 • 144 citations

Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells.

1982 • 123 citations

REMISSION INDUCTION WITH ADENOSINE-DEAMINASE INHIBITOR 2'-DEOXYCOFORMYCIN IN THY-LYMPHOBLASTIC LEUKÆMIA

1980 • 113 citations

Metabolism and chemotherapeutic activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase.

1980 • 112 citations

ATP depletion as a consequence of adenosine deaminase inhibition in man.

1980 • 108 citations

Synthesis and biological activity of selected 2,6-disubstituted(2-deoxy-.alpha.- and -.beta.-D-erythro-pentofuranosyl)purines

1972 • 107 citations

Clinical pharmacology of deoxycoformycin

1981 • 107 citations

Comparison of the toxicity and metabolism of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine in human lymphoblastoid cells.

1980 • 101 citations

Phase I study of 2'-deoxycoformycin in acute lymphoblastic leukemia.

1981 • 88 citations

Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo

1980 • 75 citations

Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase.

1982 • 70 citations

Differences in metabolism and cytotoxicity between 9-beta-D arabinofuranosyladenine and 9-beta-D-arabinofuranosyl-2-fluoroadenine in human leukemic lymphoblasts.

1980 • 59 citations

Treatment of acute lymphoblastic leukemia with 2'-deoxycoformycin: clinical and biochemical consequences of adenosine deaminase inhibition.

1979 • 58 citations

Has the well gone dry? The First Cain Memorial Award Lecture.

1982 • 52 citations