An application of Pavlovian principles to the problems of obesity and cognitive decline

A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement

1972 • 6,687 citations

Global nutrition transition and the pandemic of obesity in developing countries

2012 • 3,785 citations

Context and Behavioral Processes in Extinction: Table 1.

2004 • 1,677 citations

Suppressing unwanted memories by executive control

2001 • 1,072 citations

Probability of shock in the presence and absence of cs in fear conditioning.

1968 • 1,051 citations

Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

2006 • 823 citations

A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment

2011 • 662 citations

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

2009 • 651 citations

Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity

2010 • 609 citations

The work of the digestive glands

1902 • 537 citations

Fueling the Obesity Epidemic? Artificially Sweetened Beverage Use and Long‐term Weight Gain

2008 • 452 citations

Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels

2010 • 420 citations

Stimulus selection in animal discrimination learning.

1968 • 419 citations

Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry

2012 • 378 citations

Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements

2013 • 377 citations

A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

2008 • 351 citations

Opposing Mechanisms Support the Voluntary Forgetting of Unwanted Memories

2012 • 323 citations

Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake

2004 • 306 citations

A role for sweet taste: Calorie predictive relations in energy regulation by rats.

2008 • 296 citations

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

2008 • 284 citations

The neurobiology of food intake in an obesogenic environment

2012 • 275 citations

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

2011 • 275 citations

The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat

2010 • 274 citations

What Causes Humans to Begin and End a Meal? A Role for Memory for What Has Been Eaten, as Evidenced by a Study of Multiple Meal Eating in Amnesic Patients

1998 • 258 citations

Context, Ambiguity, and Classical Conditioning

1994 • 251 citations

Epidemiology of Obesity in the Western Hemisphere

2008 • 250 citations

Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct

2013 • 242 citations

Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale–European Prospective Investigation into Cancer and Nutrition cohort

2013 • 235 citations

Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides

2011 • 233 citations

Anticipatory physiological regulation in feeding biology: Cephalic phase responses

2007 • 232 citations

Cephalic phase responses and appetite

2010 • 231 citations

The Relation of Adiposity to Cognitive Control and Scholastic Achievement in Preadolescent Children

2012 • 227 citations

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load

2013 • 219 citations

Differential Effects of Dorsal and Ventral Hippocampal Lesions

1998 • 216 citations

Conditioned taste aversion as a learning and memory paradigm

2001 • 209 citations

Caffeinated and caffeine-free beverages and risk of type 2 diabetes

2012 • 207 citations

High-intensity sweeteners and energy balance

2010 • 207 citations

A role for hippocampus in the utilization of hunger signals

1993 • 206 citations

Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation

2008 • 188 citations

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

2012 • 184 citations

Diminished ability to interpret and report internal states after bilateral medial temporal resection: Case H.M.

1985 • 180 citations

Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects

2011 • 179 citations

Memory inhibition and energy regulation

2005 • 176 citations

Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

2011 • 176 citations

Diminished ability to interpret and report internal states after bilateral medial temporal resection: Case H.M.

1985 • 169 citations

Memory for recent eating and its influence on subsequent food intake

2002 • 168 citations

Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry

2006 • 161 citations

Modulatory mechanisms in Pavlovian conditioning

1995 • 160 citations

Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans

2011 • 152 citations

Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

2010 • 149 citations

Cholecystokinin

2012 • 149 citations

The role of the gut/brain axis in modulating food intake

2011 • 149 citations

Cognitive influences on food intake: The effects of manipulating memory for recent eating

2008 • 147 citations

Dietary patterns matter: diet beverages and cardiometabolic risks in the longitudinal Coronary Artery Risk Development in Young Adults (CARDIA) Study

2012 • 145 citations

A Pavlovian approach to the problem of obesity

2004 • 143 citations

Eating beyond metabolic need: how environmental cues influence feeding behavior

2013 • 141 citations

Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects

2010 • 138 citations

Inhibitory control of memory retrieval and motor processing associated with the right lateral prefrontal cortex: Evidence from deficits in individuals with ADHD

2010 • 137 citations

Diet Soft Drink Consumption is Associated with an Increased Risk of Vascular Events in the Northern Manhattan Study

2012 • 135 citations

Learned Controls of Ingestive Behaviour

1997 • 134 citations

Altered processing of sweet taste in the brain of diet soda drinkers

2012 • 132 citations

Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier

2011 • 131 citations

Focusing on food during lunch enhances lunch memory and decreases later snack intake

2011 • 130 citations

Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

2009 • 129 citations

Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease

2013 • 122 citations

Episodic Memory and Appetite Regulation in Humans

2012 • 121 citations

Television food advertising and the prevalence of childhood overweight and obesity: a multicountry comparison

2009 • 120 citations

Association of Sweetened Beverage Intake with Incident Hypertension

2012 • 114 citations

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels

2012 • 109 citations

Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats

2012 • 107 citations

General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.

2009 • 102 citations

Differential effects of reinforcement of an inhibitory feature after serial and simultaneous feature negative discrimination training.

1984 • 101 citations

A neuroanatomical model of prefrontal inhibitory modulation of memory retrieval

2012 • 100 citations

Hippocampal lesions interfere with Pavlovian negative occasion setting

1999 • 99 citations

Potential Predictors of Hippocampal Atrophy in Alzheimerʼs Disease

2010 • 98 citations

Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women

2011 • 98 citations

Reconsideration of the role of the hippocampus in learned inhibition

2001 • 98 citations

Intake of High-Intensity Sweeteners Alters the Ability of Sweet Taste to Signal Caloric Consequences: Implications for the Learned Control of Energy and Body Weight Regulation

2011 • 98 citations

37 Years of Body Mass Index and Dementia: Observations from the Prospective Population Study of Women in Gothenburg, Sweden

2012 • 97 citations

Little and often: Ingestive behavior patterns following hippocampal lesions in rats.

1998 • 97 citations

Hippocampal lesions impair retention of discriminative responding based on energy state cues.

2010 • 96 citations

The nature and function of interoceptive signals to feed: Toward integration of physiological and learning perspectives.

1993 • 94 citations

Effects of Diet Soda on Gut Hormones in Youths With Diabetes

2012 • 94 citations

T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to polycose: implications for saccharide taste receptors in mice

2009 • 92 citations

Little and often: Ingestive behavior patterns following hippocampal lesions in rats.

1998 • 88 citations

Hippocampal-Prefrontal Cortical Circuit Mediates Inhibitory Response Control in the Rat

2012 • 83 citations

Hippocampal neurons inhibit meal onset

2012 • 78 citations

Cognitive Function and Overweight in Preschool Children

2009 • 74 citations

Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats.

2013 • 73 citations

Learning about deprivation intensity stimuli.

1987 • 72 citations

Amygdala response to sucrose consumption is inversely related to artificial sweetener use

2011 • 68 citations

Direct Evidence for the Role of Inhibition in Resolving Interference in Memory

2010 • 67 citations

Learning about deprivation intensity stimuli.

1987 • 62 citations

Satiety signals and obesity

2013 • 57 citations

The hippocampus as a common target of neurotoxic agents

1988 • 57 citations

Contextual control of appetite. Renewal of inhibited food-seeking behavior in sated rats after extinction

2011 • 54 citations

The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation

2005 • 52 citations

Gastric distention induced functional magnetic resonance signal changes in the rodent brain

2011 • 49 citations

Sucrose taste but not Polycose taste conditions flavor preferences in rats

2008 • 37 citations

Potency of food deprivation intensity cues as discriminative stimuli.

1992 • 35 citations

Retrieval Inhibition and Memory Distortion

2008 • 33 citations

Fat substitutes promote weight gain in rats consuming high-fat diets.

2011 • 27 citations

Interoceptive sensory signals produced by 24-hr food deprivation, pharmacological glucoprivation, and lipoprivation.

1996 • 27 citations

Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men

2014 • 26 citations

Novel findings in the cephalic phase of digestion: A role for microcirculation?

2011 • 26 citations

Interoceptive “satiety” signals produced by leptin and CCK

2007 • 24 citations

The effects of selective ibotenate lesions of the hippocampus on conditioned inhibition and extinction

2003 • 24 citations

Overeating by Young Obesity‐prone and Lean Rats Caused by Tastes Associated With Low Energy Foods

2007 • 24 citations

Potency of food deprivation intensity cues as discriminative stimuli.

1992 • 23 citations

Cue interactions in flavor preference learning: A configural analysis.

2011 • 21 citations

A Review of the Empirical Laws of Basic Learning in Pavlovian Conditioning

2004 • 21 citations

Adiposity signaling and meal size control

2010 • 19 citations

Stimulus competition between a discrete cue and a training context: Cue competition does not result from the division of a limited resource.

2009 • 11 citations

Transfer across unconditioned stimuli in serial feature discrimination training.

2002 • 8 citations