Adiposity signaling and meal size control

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice

1997 • 435 citations

Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

2002 • 374 citations

Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size

2004 • 322 citations

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

2004 • 291 citations

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

2010 • 232 citations

Leptin action in the forebrain regulates the hindbrain response to satiety signals

2005 • 219 citations

Central leptin modulates behavioral and neural responsivity to CCK

1999 • 218 citations

Leptin action in the forebrain regulates the hindbrain response to satiety signals

2005 • 201 citations

Metabolic hormones and regulation of body weight.

1974 • 185 citations

Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation

2006 • 177 citations

Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting.

1998 • 173 citations

Differential expression of mRNA for leptin receptor isoforms in the rat brain

1997 • 172 citations

Central insulin enhances sensitivity to cholecystokinin

1995 • 168 citations

Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin

2003 • 162 citations

Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats

1998 • 157 citations

Fos expression in the brain induced by peripheral injection of CCK or leptin plus CCK in fasted lean mice

1998 • 141 citations

Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin**This work was supported by grants from the NIH (DK-12829, DK-52989, and NS-32272) and by the Royalty Research Fund, the Diabetes Endocrinology Research Center, and the Clinical Nutrition Research Unit of the University of Washington.

2000 • 128 citations

Leptin and Neuropeptide Y Have Opposing Modulatory Effects on Nucleus of the Solitary Tract Neurophysiological Responses to Gastric Loads: Implications for the Control of Food Intake

2002 • 118 citations

Mode of action of OB protein (leptin) on feeding

1998 • 118 citations

Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload

2001 • 76 citations

A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain

2010 • 75 citations

Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats

1998 • 75 citations

Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons

1986 • 68 citations

Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition

2002 • 63 citations

Hindbrain GRP receptor blockade antagonizes feeding suppression by peripherally administered GRP

1996 • 56 citations

Distribution of bombesin-like immunoreactivity in the nucleus of the solitary tract and dorsal motor nucleus of the rat and human: Colocalization with tyrosine hydroxylase

1996 • 37 citations

Leptin modulation of peripheral controls of meal size

2006 • 30 citations

Leptin enhances feeding suppression and neural activation produced by systemically administered bombesin

2005 • 28 citations

Gastrin-Releasing Peptide Messenger Ribonucleic Acid Expression in the Hypothalamic Paraventricular Nucleus Is Altered by Melanocortin Receptor Stimulation and Food Deprivation

2008 • 22 citations

GRP mediates an inhibitory response of gut-related vagal motor neurons to PVN stimulation

2002 • 4 citations