Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry
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References (59)
Behavioral despair in mice: a primary screening test for antidepressants.
1977 • 3,241 citations
Neurobiology of Depression
2002 • 3,057 citations
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
2006 • 2,533 citations
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
2006 • 1,997 citations
The Mesolimbic Dopamine Reward Circuit in Depression
2006 • 1,931 citations
Brain dopamine and obesity
2001 • 1,817 citations
New approaches to antidepressant drug discovery: beyond monoamines
2006 • 1,530 citations
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
1998 • 1,504 citations
Association Between Obesity and Psychiatric Disorders in the US Adult Population
2006 • 1,304 citations
The many faces of CREB
2005 • 1,282 citations
Molecular mechanisms of drug addiction
2004 • 1,080 citations
Mouse and rat BDNF gene structure and expression revisited
2006 • 892 citations
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior
2011 • 875 citations
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
1999 • 825 citations
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
1997 • 788 citations
BDNF regulates eating behavior and locomotor activity in mice
2000 • 788 citations
Regulation of Cocaine Reward by CREB
1998 • 762 citations
Prospective association between obesity and depression: evidence from the Alameda County Study
2003 • 655 citations
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
2006 • 615 citations
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
1999 • 557 citations
Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors
2008 • 554 citations
Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens
2001 • 508 citations
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
2002 • 506 citations
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
2001 • 475 citations
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
2010 • 463 citations
Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene
2006 • 460 citations
Molecular Neurobiology of Addiction
2001 • 406 citations
ΔFosB: a molecular switch for long-term adaptation in the brain
2004 • 395 citations
Depression and anxiety among US adults: associations with body mass index
2009 • 377 citations
Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity
2009 • 376 citations
Common Molecular and Cellular Substrates of Addiction and Memory
2002 • 361 citations
CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits
2009 • 333 citations
cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs
2002 • 330 citations
Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome
2008 • 329 citations
Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat.
2008 • 300 citations
High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat
1997 • 295 citations
Relationship of obesity to depression: a family-based study
2004 • 237 citations
ΔFosB: a molecular mediator of long-term neural and behavioral plasticity1Published on the World Wide Web on 27 November 1998.1
1999 • 236 citations
Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity
2011 • 227 citations
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
2007 • 222 citations
Ca2+-sensing receptors in intestinal epithelium
1997 • 211 citations
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
2006 • 211 citations
Evidence for defective mesolimbic dopamine exocytosis in obesity‐prone rats
2008 • 182 citations
Central and Medial Amygdaloid Brain-Derived Neurotrophic Factor Signaling Plays a Critical Role in Alcohol-Drinking and Anxiety-Like Behaviors
2006 • 174 citations
Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats
2010 • 174 citations
Regulation of Drug Reward by cAMP Response Element-Binding Protein: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area
2005 • 166 citations
Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
2005 • 162 citations
Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment
2009 • 157 citations
Appetite and reward
2009 • 157 citations
High-fat diet selectively protects against the effects of chronic social stress in the mouse
2011 • 153 citations
Brain-Derived Neurotrophic Factor Regulates Hedonic Feeding by Acting on the Mesolimbic Dopamine System
2010 • 132 citations
Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: Role of hippocampus
2010 • 128 citations
Molecular and genetic substrates linking stress and addiction
2009 • 122 citations
BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events
2004 • 118 citations
ΔFosB-Mediated Alterations in Dopamine Signaling Are Normalized by a Palatable High-Fat Diet
2008 • 66 citations
Role of Cdk5 in Drug Abuse and Plasticity
2004 • 64 citations
CREB Gene Transcription Factors: Role in Molecular Mechanisms of Alcohol and Drug Addiction
2005 • 58 citations
The Nuclear Transcription Factor CREB: Involvement in Addiction, Deletion Models and Looking Forward
2007 • 43 citations
The mesolimbic dopaminergic response to novel palatable food consumption increases dopamine‐D1 receptor‐mediated signalling with complex modifications of the DARPP‐32 phosphorylation pattern
2005 • 31 citations