Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

Vinorelbine plus Cisplatin vs. Observation in Resected Non–Small-Cell Lung Cancer

2005 • 1,755 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

Hallmarks of senescence in carcinogenesis and cancer therapy

2004 • 489 citations

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

1999 • 479 citations

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues

1998 • 386 citations

Telomerase: A target for cancer therapeutics

2002 • 331 citations

Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway.

2002 • 227 citations

High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage

1997 • 194 citations

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells

2001 • 193 citations

Regulation of the human telomerase reverse transcriptase gene

2002 • 186 citations

Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay.

2000 • 185 citations

Frequent amplification of the telomerase reverse transcriptase gene in human tumors.

2000 • 157 citations

Chromosome rearrangements resulting from telomere dysfunction and their role in cancer

2004 • 155 citations

Prognostic Factors in Resected Stage I Non–Small-Cell Lung Cancer: A Multivariate Analysis of Six Molecular Markers

2004 • 145 citations

Differential expression of Met/hepatocyte growth factor receptor in subtypes of non-small cell lung cancers

1998 • 114 citations

Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization

2001 • 113 citations

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours

2004 • 98 citations

Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas

2001 • 91 citations

The significance of telomerase activation and cellular immortalization in human cancer

2002 • 87 citations

hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer.

2002 • 85 citations

Skp2 Gene Copy Number Aberrations Are Common in Non-Small Cell Lung Carcinoma, and Its Overexpression in Tumors with ras Mutation Is a Poor Prognostic Marker

2004 • 80 citations

Prognostic Impact of Telomerase Activity in Non-Small Cell Lung Cancers

1999 • 80 citations

hTERT Gene Amplification and Increased mRNA Expression in Central Nervous System Embryonal Tumors

2003 • 67 citations

Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer

2001 • 58 citations

Clinical implications of quantitative real-time RT–PCR analysis of hTERT gene expression in human gliomas

2003 • 57 citations

The diagnostic and prognostic relevance of human telomerase reverse transcriptase mRNA expression detected in situ in patients with nonsmall cell lung carcinoma

2003 • 53 citations

Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas

2002 • 52 citations

Full-Length Telomerase Reverse Transcriptase Messenger RNA Is an Independent Prognostic Factor in Neuroblastoma

2003 • 50 citations

Prediction of Survival in Stage I Lung Carcinoma Patients by Telomerase Function Evaluation

2002 • 49 citations

Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas

2003 • 45 citations

Drug Insight: cancer cell immortality—telomerase as a target for novel cancer gene therapies

2004 • 45 citations

hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines

2002 • 44 citations

Association Between Telomerase Activity and Outcome in Patients With Nonmetastatic Ewing Family of Tumors

2003 • 42 citations

Expression of human telomerase subunit genes in primary lung cancer and its clinical significance

2000 • 41 citations

Prognostic significance of telomeric repeat length alterations in pathological stage I-IIIA non-small cell lung cancer.

2000 • 38 citations

Prognostic significance of hTERT expression in non-small cell lung cancer.

2000 • 37 citations

Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer

2001 • 31 citations

Telomerase activity in central nervous system malignant lymphoma

1999 • 28 citations

Correlation between telomerase expression and terminal restriction fragment length ratio in non-small cell lung cancer—an adjusted measurement and its clinical significance

2004 • 21 citations

Immune function, telomerase, and angiogenesis in patients with primary, operable nonsmall cell lung carcinoma

2001 • 21 citations

Expression and alternative splicing pattern of human telomerase reverse transcriptase in human lung cancer cells

2004 • 13 citations

Pemphigus Foliaceus

2005 • 12 citations