Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
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References (54)
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
1987 • 64,270 citations
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
1987 • 45,673 citations
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
1994 • 7,043 citations
Telomeres shorten during ageing of human fibroblasts
1990 • 5,530 citations
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 • 4,845 citations
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
1985 • 3,331 citations
A survey of telomerase activity in human cancer
1997 • 2,747 citations
Creation of human tumour cells with defined genetic elements
1999 • 2,333 citations
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
1997 • 2,256 citations
The RNA Component of Human Telomerase
1995 • 2,243 citations
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
1997 • 1,786 citations
A theory of marginotomy
1973 • 1,770 citations
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 • 1,607 citations
Origin of Concatemeric T7DNA
1972 • 1,591 citations
Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
1997 • 1,252 citations
Inhibition of telomerase limits the growth of human cancer cells
1999 • 1,032 citations
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
1998 • 1,001 citations
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
1997 • 946 citations
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
1998 • 629 citations
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
1998 • 614 citations
Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types
1997 • 586 citations
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
1999 • 545 citations
Functional requirement of p23 and Hsp90 in telomerase complexes
1999 • 538 citations
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts.
1998 • 493 citations
Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity
1995 • 490 citations
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.
1989 • 481 citations
The two-stage mechanism controlling cellular senescence and immortalization
1992 • 377 citations
Reconstitution of human telomerase activity in vitro
1998 • 347 citations
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
2000 • 329 citations
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer.
1998 • 301 citations
Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
1999 • 270 citations
The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity
2000 • 223 citations
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes
2000 • 221 citations
An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity
2000 • 209 citations
Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
2000 • 179 citations
Both Transcriptional and Posttranscriptional Mechanisms Regulate Human Telomerase Template RNA Levels
1999 • 164 citations
Lack of cell cycle regulation of telomerase activity in human cells
1997 • 162 citations
Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer.
1998 • 139 citations
Reversible Cellular Senescence: Implications for Immortalization of Normal Human Diploid Fibroblasts
1989 • 129 citations
Telomerase Activity Does Not Always Imply Telomere Maintenance
1999 • 108 citations
In situ hybridization for the detection of telomerase RNA in the progression from barrett's esophagus to esophageal adenocarcinoma
1998 • 108 citations
High telomerase reverse transcriptase (hTERT) messenger RNA level correlates with tumor recurrence in patients with favorable histology Wilms' tumor.
1999 • 103 citations
One-step affinity purification protocol for human telomerase
1998 • 99 citations
Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
1999 • 85 citations
Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells.
2000 • 49 citations
In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies
1998 • 47 citations
Expression of telomerase component genes in hepatocellular carcinomas
2000 • 39 citations
Re-expression of senescent markers in deinduced reversibly immortalized cells
1992 • 39 citations
Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.
2000 • 32 citations
In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion
1994 • 30 citations
Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
2000 • 16 citations
Telomere Dynamics in Cells with Introduced Telomerase: A Rapid Assay for Telomerase Activity on Telomeres
2000 • 16 citations
Detection of telomerase in hepatocellular carcinomas using a PCR ELISA assay: comparison with hTR expression
1999 • 12 citations
In situ hybridization for the detection of telomerase RNA in the progression from barrett's esophagus to esophageal adenocarcinoma
1998 • 11 citations
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