Drug Insight: cancer cell immortality—telomerase as a target for novel cancer gene therapies

Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

2002 • 475 citations

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

1999 • 473 citations

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

1999 • 404 citations

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

1998 • 332 citations

Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)

1999 • 270 citations

Phase I Trial of Intraperitoneal Injection of the E1B-55-kd-Gene-Deleted Adenovirus ONYX-015 (dl1520) Given on Days 1 Through 5 Every 3 Weeks in Patients With Recurrent/Refractory Epithelial Ovarian Cancer

2002 • 251 citations

Telomerase-Specific Replication-Selective Virotherapy for Human Cancer

2004 • 241 citations

Gene therapy: designer promoters for tumour targeting

2000 • 222 citations

Expression of mouse telomerase catalytic subunit in embryos and adult tissues

1998 • 216 citations

Telomerase inhibitors

2001 • 169 citations

Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?

2002 • 169 citations

A Telomerase-dependent Conditionally Replicating Adenovirus for Selective Treatment of Cancer

2003 • 168 citations

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

2001 • 137 citations

Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.

2001 • 130 citations

Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

2004 • 129 citations

Telomerase-dependent oncolytic adenovirus for cancer treatment

2003 • 125 citations

A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter

2000 • 113 citations

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

2001 • 113 citations

Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors

2001 • 111 citations

Ad-mTERT-Δ19, a Conditional Replication-Competent Adenovirus Driven by the Human Telomerase Promoter, Selectively Replicates in and Elicits Cytopathic Effect in a Cancer Cell-Specific Manner

2003 • 107 citations

Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954

2001 • 100 citations

Targeted expression of green fluorescent protein/tumor necrosis factor-related apoptosis-inducing ligand fusion protein from human telomerase reverse transcriptase promoter elicits antitumor activity without toxic effects on primary human hepatocytes.

2002 • 89 citations

Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity

2004 • 86 citations

hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

2002 • 86 citations

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

2003 • 81 citations

Telomerase Activity Reconstituted in Vitro with Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component

2000 • 80 citations

Replication of an adenoviral vector controlled by the human telomerase reverse transcriptase promoter causes tumor-selective tumor lysis.

2003 • 78 citations

Tumour specific regulation of telomerase RNA gene expression visualized by in situ hybridization

1998 • 76 citations

Cloning and characterization of human and mouse telomerase RNA gene promoter sequences

1998 • 76 citations

Cancer gene therapy: an awkward adolescence

2003 • 71 citations

Comparison of Human Telomerase RNA and Telomerase Activity in Urine for Diagnosis of Bladder Cancer

1999 • 71 citations

Telomerase: a therapeutic target for the third millennium?

2000 • 69 citations

Noninvasive Imaging of the Transcriptional Activities of Human Telomerase Promoter Fragments in Mice

2004 • 65 citations

A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent

2004 • 57 citations

Activation of Telomerase RNA Gene Promoter Activity by NF-Y, Sp1, and the Retinoblastoma Protein and Repression by Sp3

2000 • 48 citations

A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo

2002 • 47 citations

Telomerase-directed molecular therapeutics

2002 • 47 citations

Telomerase and cancer: time to move from a promising target to a clinical reality

2001 • 47 citations

Suppressing Orthotopic Pancreatic Tumor Growth with a Fiber-Modified Adenovector Expressing the TRAIL Gene from the Human Telomerase Reverse Transcriptase Promoter

2004 • 47 citations

The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylation

2002 • 44 citations

Tumor-Specific Gene Therapy for Undifferentiated Thyroid Carcinoma Utilizing the Telomerase Reverse Transcriptase Promoter

2003 • 40 citations

FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo.

2001 • 40 citations

A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter

2001 • 37 citations

Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter

2002 • 33 citations

Enhanced suicide gene therapy by chimeric tumor‐specific promoter based on HSF1 transcriptional regulation

2003 • 16 citations

Principles of chemotherapy and drug development

2008 • 5 citations

Cited By (0)

No citing papers found in database