Mismatch repair and cancer susceptibility

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

A mechanism for gene conversion in fungi

1964 • 1,459 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

1992 • 590 citations

DNA Mismatch Correction in a Defined System

1989 • 551 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

1994 • 495 citations

Common Inheritance of Susceptibility to Colonic Adenomatous Polyps and Associated Colorectal Cancers

1988 • 472 citations

Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli

1984 • 468 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction.

1980 • 391 citations

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

1994 • 366 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

1986 • 353 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Initiation of methyl-directed mismatch repair.

1992 • 313 citations

Repair tracts in mismatched DNA heteroduplexes.

1976 • 300 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

1994 • 287 citations

Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

1990 • 253 citations

Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs.

1994 • 251 citations

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

1994 • 236 citations

Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells

1988 • 230 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

Meiotic Gene Conversion: A Signal of the Basic Recombination Event in Yeast

1979 • 221 citations

MEIOTIC GENE CONVERSION MUTANTS IN SACCHAROMYCES CEREVISIAE. I. ISOLATION AND CHARACTERIZATION OF pms1-1 AND pms1-2

1985 • 220 citations

The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.

1993 • 216 citations

Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli.

1992 • 215 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Methyl-directed mismatch repair is bidirectional

1993 • 208 citations

A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine

1987 • 201 citations

RADH, a gene ofSaccharomyces cerevisiaeencoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene

1989 • 194 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA.

1984 • 175 citations

Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes.

1989 • 164 citations

Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.

1988 • 152 citations

One role for DNA methylation in vertebrate cells is strand discrimination in mismatch repair.

1985 • 148 citations

Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.

1994 • 146 citations

The yeast gene MSH3 defines a new class of eukaryotic MutS homologues

1993 • 140 citations

Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.

1991 • 140 citations

Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry

1993 • 119 citations

Bacterial genes mutL, mutS, and dcm participate in repair of mismatches at 5-methylcytosine sites

1987 • 117 citations

Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria.

1986 • 112 citations

Repair of a Mismatch Is Influenced by the Base Composition of the Surrounding Nucleotide Sequence

1987 • 112 citations

Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis.

1990 • 107 citations

GATC sequences, DNA nicks and the MutH function in Escherichia coli mismatch repair.

1987 • 101 citations

Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA.

1989 • 98 citations

HYPER-RECOMBINING RECIPIENT STRAINS IN BACTERIAL CONJUGATION

1986 • 98 citations

Effect of base pair mismatches on recombination via the RecBCD pathway

1989 • 91 citations

The role of heteroduplex correction in gene conversion in Saccharomyces cerevisiae

1987 • 86 citations

How prevalent is cancer family syndrome?

1991 • 81 citations

DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches.

1990 • 65 citations

Mismatch correction catalyzed by cell-free extracts of Saccharomyces cerevisiae.

1986 • 59 citations

Involvement of Escherichia coli Mismatch Repair in DNA Replication and Recombination

1984 • 59 citations

Repair of hEteroduplex Plasmid DNA after Transformation into Saccharomyces cerevisiae

1986 • 58 citations

Measurement of Restoration and Conversion: Its Meaning for the Mismatch Repair Hypothesis of Conversion

1984 • 54 citations

Recombinagenic processing of UV-light photoproducts in nonreplicating phage DNA by the Escherichia coli methyl-directed mismatch repair system.

1991 • 48 citations

Repair of base–base mismatches in simian and human cells

1989 • 43 citations

Genetic recombination

1989 • 43 citations

Effects of multiple yeast rad3 mutant alleles on UV sensitivity, mutability, and mitotic recombination

1990 • 38 citations

Some Features of Base Pair Mismatch and Heterology Repair in Escherichia coli

1987 • 34 citations

Influence of GATC sequences on Escherichia coli DNA mismatch repair in vitro

1987 • 30 citations

Repair of heteroduplex plasmid DNA after transformation into Saccharomyces cerevisiae.

1986 • 30 citations

Mutation of an mutL Homologue in a Navajo Family With Hereditary Nonpolyposis Colorectal Cancer

1994 • 28 citations

Gene conversion in Escherichia coli: the recF pathway for resolution of heteroduplex DNA

1989 • 24 citations

Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes

1994 • 15 citations

Strand targeting signal(s) for in vivo mutation avoidance by post-replication mismatch repair in Escherichia coli

1988 • 13 citations

Antibiotic resistance in laboratory workers

1976 • 7 citations