β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

The prevalence of dementia: A quantitative integration of the literature

1987 • 1,300 citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

2001 • 988 citations

The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

1991 • 801 citations

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

2001 • 706 citations

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

2002 • 699 citations

β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

2002 • 678 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease

2002 • 559 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease

1987 • 472 citations

Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme

2000 • 404 citations

Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons

2002 • 363 citations

Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding

2001 • 301 citations

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

2001 • 301 citations

Phosphorylation Regulates Intracellular Trafficking of β-Secretase

2001 • 275 citations

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

2003 • 274 citations

Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys

1973 • 270 citations

Maturation and Pro-peptide Cleavage of β-Secretase

2000 • 247 citations

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

2001 • 216 citations

Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease

2002 • 207 citations

Region‐specific reduction of Aβ‐degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

2002 • 197 citations

Senile plaques in cortex of aged normal monkeys

1985 • 186 citations

Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease

2002 • 152 citations

Astrocytic expression of the Alzheimer's disease β‐secretase (BACE1) is stimulus‐dependent

2002 • 151 citations

The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain

2001 • 124 citations

Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-secretase) Studied with New Fluorogenic Substrates

2000 • 123 citations

The neural basis of memory decline in aged monkeys

1988 • 121 citations

Expression of human β‐secretase in the mouse brain increases the steady‐state level of β‐amyloid

2002 • 120 citations

The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta 42(43)

1997 • 111 citations

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.

1996 • 109 citations

Neuronal and glial β‐secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

2001 • 103 citations

Lack of correlation between plaque burden and cognition in the aged monkey

1997 • 99 citations

β-Site APP Cleaving Enzyme mRNA Expression in APP Transgenic Mice

2001 • 68 citations

Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression

1997 • 68 citations

Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

2001 • 65 citations

Identification of Phospholipid Scramblase 1 as a Novel Interacting Molecule with β-Secretase (β-Site Amyloid Precursor Protein (APP) Cleaving Enzyme (BACE))

2003 • 54 citations

Localization of β-Secretase Memapsin 2 in the Brain of Alzheimer's Patients and Normal Aged Controls

2002 • 43 citations

Endoproteolysis of औ-Secretase (औ-Site Amyloid Precursor Protein-cleaving Enzyme) within Its Catalytic Domain

2003 • 39 citations

Age-related changes in the localization of presenilin-1 in cynomolgus monkey brain

2001 • 37 citations

BACE1 interacts with nicastrin

2002 • 34 citations

Presenilin-1, amyloid precursor protein and amyloid precursor-like protein 2 mRNA levels in human superior frontal cortex during aging

1997 • 13 citations

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