A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

1982 • 421 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.

1977 • 188 citations

The lupus activity criteria count (LACC).

1984 • 165 citations

Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus

1984 • 159 citations

The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.

1987 • 153 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Lymphocyte Activation by the Tumor-Promoting Agent 12-O-Tetradecanoylphorbol-13-Acetate (TPA)

1979 • 145 citations

The interleukin 2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells.

1986 • 111 citations

Human T lymphocyte activation by tumor promoters: role of protein kinase C.

1987 • 106 citations

Immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen.

1979 • 99 citations

Lymphocyte reactivity to mitogens in subjects with systemic lupus erythematosus, rheumatoid arthritis and scleroderma.

1977 • 70 citations

Impaired T cell capping and receptor regeneration in active systemic lupus erythematosus. Evidence for a disorder intrinsic to the T lymphocyte.

1983 • 50 citations

Reaction of T lymphocytes with anti-T3 induces translocation of C-kinase activity to the membrane and specific substrate phosphorylation.

1987 • 47 citations

Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens

1989 • 38 citations

Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis.

1988 • 38 citations

Characterization of protein kinase C and its isoforms in human T lymphocytes.

1988 • 38 citations

Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.

1987 • 37 citations

Impaired immunoregulation in systemic lupus erythematosus: defective adenosine-induced suppressor T lymphocyte generation.

1983 • 37 citations

Defective cAMP-dependent phosphorylation of intact T lymphocytes in active systemic lupus erythematosus.

1990 • 34 citations

Antigen-specific and -nonspecific mitogenic signals in the activation of human T cell clones.

1987 • 33 citations

Deficient phytohemagglutinin‐induced interleukin‐2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate

1988 • 28 citations

Phytohemagglutinin Response in Systemic Lupus Erythematosus

1977 • 23 citations

Deficient protein kinase C-dependent Na+/H+ exchanger activity in T cells from bone marrow transplantation recipients.

1989 • 14 citations

Activation of protein kinase C induces differentiation in the human T-lymphoblastic cell line MOLT-3

1989 • 12 citations