Effects of over- and under-expression of Cu,Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

[10] Superoxide dismutase assays

1984 • 1,468 citations

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1996 • 1,261 citations

Superoxide dismutases

1989 • 953 citations

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1992 • 758 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Manganese superoxide dismutase can reduce cellular damage mediated by oxygen radicals in transgenic plants.

1991 • 558 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

Markers for Gene Expression in Cultured Cells from the Nervous System

1972 • 403 citations

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

1997 • 287 citations

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

1995 • 283 citations

Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice

1994 • 265 citations

Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.

1989 • 245 citations

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

1996 • 237 citations

Elevation in the Ratio of Cu/Zn-Superoxide Dismutase to Glutathione Peroxidase Activity Induces Features of Cellular Senescence and This Effect Is Mediated by Hydrogen Peroxide

1996 • 234 citations

Chapter 31 Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration

1994 • 199 citations

Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism

1996 • 171 citations

3‐Nitropropionic Acid Neurotoxicity Is Attenuated in Copper/Zinc Superoxide Dismutase Transgenic Mice

1995 • 162 citations

STANDARDIZATION OF A RADIOCHEMICAL ASSAY OF CHOLINE ACETYLTRANSFERASE AND A STUDY OF THE ACTIVATION OF THE ENZYME IN RABBIT BRAIN

1971 • 149 citations

Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia

1993 • 126 citations

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dimutase-implication for gene dosage effects in down syndrome

1988 • 118 citations

Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

1996 • 106 citations

Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase.

1990 • 103 citations

Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells

1993 • 99 citations

Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists

1989 • 98 citations

CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA)

1994 • 93 citations

Down syndrome, Alzheimer's disease and the trisomy 16 mouse

1988 • 88 citations

Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures.

1991 • 84 citations

Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins

1990 • 80 citations

Disposition of idebenone (CV-2619), a new cerebral metabolism improving agent, in rats and dogs.

1985 • 50 citations

Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice.

1991 • 50 citations

Attenuation of Glutamate-induced Neuronal Swelling and Toxicity in Transgenic Mice Overexpressing Human CuZn-Superoxide Dismutase

1990 • 43 citations

An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines

1993 • 25 citations

A Review of in vivo modulation of cerebellar cGMP levels by excitatory amino acid receptors: role of NMDA, quisqualate and kainate subtypes

1991 • 19 citations

Mice Transgenic for Copper/Zinc Superoxide Dismutase Exhibit Increased Markers of Biogenic Amine Function

1995 • 3 citations

Simplified mounting of frozen sections of brain; drying and CHCl3 extraction prior to Nissl staining.

1969 • 2 citations