Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy

The p53 tumour suppressor gene

1991 • 3,871 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Eight-Year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Lumpectomy with or without Irradiation in the Treatment of Breast Cancer

1989 • 1,604 citations

Comparing Radical Mastectomy with Quadrantectomy, Axillary Dissection, and Radiotherapy in Patients with Small Cancers of the Breast

1981 • 1,581 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy

1995 • 458 citations

Pathologic predictors of early local recurrence in stage I and II breast cancer treated by primary radiation therapy

1984 • 360 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.

1997 • 343 citations

Molecular Biology of the Human T-Lymphotropic Retroviruses

1986 • 324 citations

Why are local recurrences after breast-conserving therapy more frequent in younger patients?

1990 • 260 citations

p53 mutations in breast cancer.

1992 • 243 citations

p53 as an Independent Prognostic Marker in Lymph Node-Negative Breast Cancer Patients

1993 • 243 citations

Abnormal expression of wild type p53 protein in normal cells of a cancer family patient

1992 • 199 citations

Ipsilateral breast tumor recurrence as a predictor of distant disease: implications for systemic therapy at the time of local relapse.

1996 • 197 citations

Predicting the rate and extent of locoregional failure after breast conservation therapy for early breast cancer

1989 • 191 citations

Prognosis following local recurrence in the conservatively treated breast cancer patient

1991 • 173 citations

p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer.

1998 • 171 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value.

1996 • 135 citations

Mammary recurrences in women younger than forty

1988 • 123 citations

Local recurrence versus new primary: Clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting

1993 • 102 citations

Prognostic factors for local recurrence in the conservatively treated breast cancer patient: a cautious interpretation of the data.

1991 • 98 citations

Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.

1994 • 83 citations

Evaluation of HER-2 neu oncoprotein expression as a prognostic indicator of local recurrence in conservatively treated breast cancer: A case-control study

1996 • 83 citations

Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence.

1998 • 53 citations

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

1997 • 34 citations

An experimental model of acute encephalopathy after total body irradiation in the rat: effect of liposome-entrapped Cu/Zn superoxide dismutase

1998 • 12 citations

TP53 mutation is an independent prognostic marker for poor outcome of radiotherapy in squamous cell carcinoma of the head and neck

1998 • 9 citations

Prognostic value of P53 for local failure in breast cancer patients treated with mastectomy or breast conserving therapy

1998 • 1 citations

Elevated frequency of germline BRCA1/BRCA2 gene mutations in locally recurrent breast cancer patients following lumpectomy and radiation therapy: Implications for breast conserving management in affected patients

1998 • 1 citations