Successes and failures of current treatment of heart failure

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

1996 • 4,580 citations

Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia

1996 • 4,078 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure

1991 • 2,867 citations

The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure

1997 • 2,867 citations

Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure

1986 • 2,409 citations

Survival after the onset of congestive heart failure in Framingham Heart Study subjects.

1993 • 1,852 citations

Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure

1993 • 1,775 citations

A Clinical Trial of the Angiotensin-Converting–Enzyme Inhibitor Trandolapril in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1995 • 1,734 citations

Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)

1997 • 1,680 citations

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy

1993 • 1,218 citations

Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

1996 • 1,182 citations

A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees.

1994 • 1,051 citations

Prophylactic Use of Implanted Cardiac Defibrillators in Patients at High Risk for Ventricular Arrhythmias after Coronary-Artery Bypass Graft Surgery

1997 • 1,015 citations

Prevalence, clinical features and prognosis of diastolic heart failure: An epidemiologic perspective

1995 • 901 citations

Readmission After Hospitalization for Congestive Heart Failure Among Medicare Beneficiaries

1997 • 836 citations

Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.

1975 • 835 citations

Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors

1993 • 795 citations

Carvedilol Inhibits Clinical Progression in Patients With Mild Symptoms of Heart Failure

1996 • 643 citations

Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population

1997 • 639 citations

Double-Blind, Placebo-Controlled Study of the Effects of Carvedilol in Patients With Moderate to Severe Heart Failure

1996 • 626 citations

Ventricular Dysfunction and the Risk of Stroke after Myocardial Infarction

1997 • 591 citations

Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: Results of the PROVED trial

1993 • 574 citations

Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease

1997 • 541 citations

Prevalence and etiology of idiopathic dilated cardiomyopathy (summary of a National Heart, Lung, and Blood Institute Workshop)

1992 • 443 citations

DOUBLE-BLIND COMPARISON OF CAPTOPRIL ALONE AGAINST FRUSEMIDE PLUS AMILORIDE IN MILD HEART FAILURE

1987 • 429 citations

Effect of propranolol after acute myocardial infarction in patients with congestive heart failure.

1986 • 416 citations

PROLONGATION OF SURVIVAL IN CONGESTIVE CARDIOMYOPATHY BY BETA-RECEPTOR BLOCKADE

1979 • 415 citations

The effects of simvastatin on the incidence of heart failure in patients with coronary heart disease

1997 • 391 citations

Effect of Beta-Blockade on Mortality in Patients With Heart Failure: A Meta-Analysis of Randomized Clinical Trials

1997 • 365 citations

Effect of the Calcium Antagonist Felodipine as Supplementary Vasodilator Therapy in Patients With Chronic Heart Failure Treated With Enalapril

1997 • 362 citations

Usefulness of verapamil for congestive heart failure associated with abnormal left ventricular diastolic filling and normal left ventricular systolic performance

1990 • 362 citations

Trends in hospitalization for heart failure in Scotland 1980-1990

1993 • 353 citations

Losartan in Heart Failure

1995 • 298 citations

The treatment of heart failure

1997 • 296 citations

Ejection Fraction and Risk of Thromboembolic Events in Patients With Systolic Dysfunction and Sinus Rhythm: Evidence for Gender Differences in the Studies of Left Ventricular Dysfunction Trials

1997 • 294 citations

The Registry of the International Society for Heart and Lung Transplantation: fourteenth official report--1997.

1997 • 288 citations

Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.

1998 • 259 citations

EFFECT OF PROPRANOLOL IN MYOCARDIAL INFARCTION

1965 • 245 citations

Effects of beta-blocker therapy on mortality in patients with heart failure: A systematic overview of randomized controlled trials

1997 • 236 citations

Experience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance

1998 • 211 citations

Mode of death in chronic heart failure: A request and proposition for more accurate classification

1996 • 209 citations

Coronary artery bypass grafting in patients with poor ventricular function

1992 • 205 citations

Comparison of the effects of losartan and enalapril on clinical status and exercise performance in patients with moderate or severe chronic heart failure

1995 • 197 citations

Clinical outcome with enalapril in symptomatic chronic heart failure; a dose comparison

1998 • 185 citations

Ischemic cardiomyopathy. Criteria for coronary revascularization and cardiac transplantation.

1991 • 167 citations

Quality of life among 5,025 patients with left ventricular dysfunction randomized between placebo and enalapril: The studies of left ventricular dysfunction

1994 • 162 citations

Prevalence, aetiology and management of heart failure in general practice.

1996 • 157 citations

Prevalence of heart failure in three general practices in north west London.

1992 • 149 citations

Increase in hospital admission rates for heart failure in The Netherlands, 1980-1993.

1996 • 141 citations

Influence of concomitant disease on patterns of hospitalization in patients with heart failure discharged from Scottish hospitals in 1995

1998 • 135 citations

Does Digoxin Provide Additional Hemodynamic and Autonomic Benefit at Higher Doses in Patients With Mild to Moderate Heart Failure and Normal Sinus Rhythm?

1997 • 135 citations

Patterns of angiotensin-converting enzyme inhibitor use in congestive heart failure in two community hospitals

1996 • 127 citations

Short- and long-acting angiotensin-converting enzyme inhibitors: A randomized trial of lisinopril versus captopril in the treatment of congestive heart failure

1989 • 127 citations

The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion

1966 • 127 citations

Comparative Effects of Losartan and Enalapril on Exercise Capacity and Clinical Status in Patients With Heart Failure fn1fn1This study was supported by a grant from Merck Research Laboratories, West Point, Pennsylvania.

1997 • 116 citations

Withdrawal of long term diuretic medication in elderly patients: a double blind randomised trial

1997 • 115 citations

National Trends in the Initial Hospitalization for Heart Failure

1997 • 115 citations

Beta-blocking agents in heart failure Should they be used and how?

1996 • 102 citations

What is the ideal study design for evaluation of treatment for heart failure?: Insights from trials assessing the effect of ACE inhibitors on exercise capacity

1996 • 96 citations

Discontinuation of chronic diuretic therapy in stable congestive heart failure secondary to coronary artery disease or to idiopathic dilated cardiomyopathy

1994 • 91 citations

Cardiac Event Rates After Acute Myocardial Infarction in Patients Treated With Verapamil and Trandolapril Versus Trandolapril Alone

1997 • 90 citations

Guidelines for the diagnosis of heart failure

1995 • 89 citations

Diltiazem Improves Cardiac Function and Exercise Capacity in Patients With Idiopathic Dilated Cardiomyopathy

1996 • 86 citations

SYMPTOMATIC ASSESSMENT OF PATIENTS WITH HEART FAILURE: DOUBLE-BLIND COMPARISON OF INCREASING DOSES OF DIURETICS AND CAPTOPRIL IN MODERATE HEART FAILURE

1986 • 84 citations

Clinical outcome with enalapril in symptomatic chronic heart failure; a dose comparison The NETWORK investigators

1998 • 79 citations

Mild systolic dysfunction in heart failure (left ventricular ejection fraction >35%): Baseline characteristics, prognosis and response to therapy in the vasodilator in heart failure trials (V-HeFT)

1996 • 79 citations

Predicting survival after coronary revascularization for ischemic cardiomyopathy

1995 • 78 citations

Effects of enalapril on long-term mortality in severe congestive heart failure

1992 • 76 citations

Long-term mechanical circulatory support as a bridge to transplantation, for recovery from cardiomyopathy, and for permanent replacement

1997 • 68 citations

Anticoagulant and antiplatelet therapy in heart failure

1997 • 67 citations

Oral torsemide in patients with chronic congestive heart failure: effects on body weight, edema, and electrolyte excretion. Torsemide Investigators Group.

1994 • 67 citations

Effects of two different enalapril dosages on clinical, haemodynamic and neurohumoral response of patients with severe congestive heart failure

1996 • 62 citations

Combination neurohormonal blockade with ACE inhibitors, angiotensin II antagonists and beta-blockers in patients with congestive heart failure: design of the Randomized Evaluation of Strategies for Left Ventricular Dysfunction (RESOLVD) Pilot Study.

1997 • 60 citations

Oral Torsemide in Patients With Chronic Congestive Heart Failure: Effects on Body Weight, Edema, and Electrolyte Excretion

1994 • 60 citations

Quality of life on treatment with Metoprolol in Dilated Cardiomyopathy: Results from the MDC trial

1996 • 47 citations

The role of calcium antagonists in the treatment of chronic heart failure

1993 • 47 citations

Renal response to candoxatrilat in patients with heart failure

1995 • 42 citations

Influence of heart size on mortality and reinfarction in patients treated with timolol after myocardial infarction.

1983 • 35 citations

Difference in mortality between patients treated with captopril or enalapril in the xamoterol in severe heart failure study

1991 • 34 citations

Successful mechanical circulatory support for more than two years with a left ventricular assist device in a patient with dilated cardiomyopathy.

1997 • 33 citations

Effects of nisoldipine therapy on myocardial perfusion and neuro-hormonal status in patients with severe ischaemic left ventricular dysfunction

1994 • 32 citations

ACE inhibitors for myocardial infarction: how should they be used?

1995 • 32 citations

ACE inhibitors for the prevention and treatment of heart failure: why are they 'under-used'?

1995 • 31 citations

Captopril in mild heart failure: preliminary observations of a long-term, double-blind, placebo-controlled multicentre trial.

1986 • 31 citations

Changing patterns of investigation and treatment of cardiac failure in hospital.

1996 • 29 citations

Severity of heart failure and dosage of angiotensin converting enzyme inhibitors

1995 • 28 citations

Patient Characteristics in Cases of Chronic Severe Heart Failure with Different Degrees of Left Ventricular Systolic Dysfunction

1994 • 27 citations

Screening For Left Ventricular Dysfunction and Chronic Heart Failure

1997 • 24 citations

Design of the cardiac insufficiency bisoprolol study II (OBIS II)

1997 • 24 citations

How do ACE inhibitors reduce mortality in patients with left ventricular dysfunction with and without heart failure: remodelling, resetting, or sudden death?

1994 • 24 citations

Development of congestive heart failure after treatment with metoprolol in acute myocardial infarction.

1984 • 22 citations

Measurement of the quality of life in congestive heart failure—Influence of drug therapy

1988 • 21 citations

A double-blind, cross-over comparison of the effects of a loop diuretic and a dopamine receptor agonist as first line therapy in patients with mild congestive heart failure

1997 • 16 citations

Acute and long-term haemodynamic and neurohumoral response to nisoldipine vs captopril in patients with heart failure: a randomized double-blind study

1990 • 15 citations

Angiography and the aetiology of heart failure

1995 • 14 citations

Prognosis of heart failure — a population-based study of the outcome in incident cases

1998 • 8 citations

Prognosis of Heart Failure - A Population-based Study of the Outcome in Incident Cases

1998 • 5 citations

Influence of Aetiology on the Effects of Treatment in Heart Failure

1999 • 5 citations

Dofetilide: A New Class III Antiarrhythmic Drug Which Is Safe in Patients With Congestive Heart Failure

1998 • 3 citations

Deleted Work

1955 • 0 citations