Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)

1997 • 1,680 citations

Genetic transformation of mouse embryos by microinjection of purified DNA.

1980 • 1,428 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

Angiotensin II type 2 receptor mediates programmed cell death.

1996 • 707 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Cardiac pacemaking in the sinoatrial node

1993 • 665 citations

Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation.

1990 • 607 citations

Expression of AT2 receptors in the developing rat fetus.

1991 • 537 citations

Cardiac Actions of Angiotensin II: Role of an Intracardiac Renin-Angiotensin System

1992 • 505 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction.

1995 • 441 citations

Cardiovascular Effects of Angiotensin Mediated by the Central Nervous System

1972 • 362 citations

Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy.

1993 • 286 citations

Angiotensin Type 2 Receptors Are Reexpressed by Cardiac Fibroblasts From Failing Myopathic Hamster Hearts and Inhibit Cell Growth and Fibrillar Collagen Metabolism

1997 • 250 citations

Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.

1991 • 249 citations

Role of Type 1 and Type 2 Angiotensin Receptors in Angiotensin II–Induced Cardiomyocyte Hypertrophy

1996 • 236 citations

Dephosphorylation of Sp1 by Protein Phosphatase 1 Is Involved in the Glucose-mediated Activation of the Acetyl-CoA Carboxylase Gene

1996 • 228 citations

Overexpression of angiotensin AT ₁ receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

1997 • 214 citations

Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts

1994 • 201 citations

Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression.

1994 • 196 citations

Mitogen-activated Protein Kinases in Rat Brain Neuronal Cultures Are Activated by Angiotensin II Type 1 Receptors and Inhibited by Angiotensin II Type 2 Receptors

1996 • 191 citations

Regulation, Chamber Localization, and Subtype Distribution of Angiotensin II Receptors in Human Hearts

1995 • 191 citations

AT ₁ and AT ₂ Angiotensin Receptor Gene Expression in Human Heart Failure

1997 • 188 citations

Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats.

1993 • 185 citations

Detection of angiotensin I and II in cultured rat cardiac myocytes and fibroblasts

1992 • 172 citations

Selective Downregulation of the Angiotensin II AT ₁ -Receptor Subtype in Failing Human Ventricular Myocardium

1997 • 172 citations

Novel Sites of Expression of Functional Angiotensin II Receptors in the Late Gestation Fetus

1989 • 161 citations

Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein

1994 • 147 citations

Electrophysiological properties of neonatal mouse cardiac myocytes in primary culture.

1994 • 139 citations

Angiotensin II-mediated Growth and Antigrowth Effects in Cultured Neonatal Rat Cardiac Myocytes and Fibroblasts

1997 • 135 citations

Cloning of cDNA and Analysis of the Gene for Mouse Angiotensin II Type 2 Receptor

1993 • 127 citations

A G Protein Is Involved in the Angiotensin AT2 Receptor Inhibition of the T-Type Calcium Current in Non-differentiated NG108-15 Cells

1995 • 124 citations

The AT2 Receptor Selectively Associates with Giα2 and Giα3 in the Rat Fetus

1996 • 123 citations

Mechanical Stretch Induces Enhanced Expression of Angiotensin II Receptor Subtypes in Neonatal Rat Cardiac Myocytes

1996 • 119 citations

Angiotensin II type 2 receptor-modulated changes in potassium currents in cultured neurons

1993 • 98 citations

Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog.

1996 • 71 citations

Phospholamban deficiency alters inactivation kinetics of L-type Ca2+ channels in mouse ventricular myocytes

1997 • 67 citations

Localization of the Angiotensin II Receptor Subtypes in the Human Atrium

1996 • 61 citations

Chronotropic effects of angiotensin I, angiotensin II, bradykinin and vasopressin in guinea pig atria

1982 • 58 citations

Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation.

1994 • 53 citations

Angiotensin II receptor subtypes in bovine and human ventricular myocardium.

1994 • 51 citations

Positive chronotropic activity of angiotensin II in the pithed normotensive rat is primarily due to activation of cardiac β1-adrenoceptors

1988 • 33 citations

Improved HPLC-radioimmunoassay for quantifying angiotensin II in plasma

1994 • 30 citations