Does Digoxin Provide Additional Hemodynamic and Autonomic Benefit at Higher Doses in Patients With Mild to Moderate Heart Failure and Normal Sinus Rhythm?

Heart Rate Variability

1996 • 15,997 citations

Heart rate variability: Standards of measurement, physiological interpretation, and clinical use

1996 • 14,140 citations

Power Spectrum Analysis of Heart Rate Fluctuation: A Quantitative Probe of Beat-to-Beat Cardiovascular Control

1981 • 4,922 citations

Decreased heart rate variability and its association with increased mortality after acute myocardial infarction

1987 • 3,955 citations

The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure

1997 • 2,867 citations

Assessment of autonomic function in humans by heart rate spectral analysis

1985 • 2,846 citations

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

1991 • 2,186 citations

Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors

1993 • 795 citations

Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure

1988 • 579 citations

Digitalis Intoxication

1971 • 579 citations

Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: Results of the PROVED trial

1993 • 574 citations

A Comparison of Oral Milrinone, Digoxin, and Their Combination in the Treatment of Patients with Chronic Heart Failure

1989 • 561 citations

Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart

1996 • 468 citations

Xamoterol in severe heart failure

1990 • 449 citations

Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings.

1989 • 383 citations

Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction

1992 • 375 citations

An Account of the Foxglove and some of its Medical Uses With Practical Remarks on Dropsy and Other Diseases

2009 • 347 citations

Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration

1970 • 341 citations

Long-Term Digitalis Therapy Improves Left Ventricular Function in Heart Failure

1980 • 303 citations

Left ventricular end-systolic stress-shortening and stress-length relations in humans

1982 • 269 citations

Studies on digitalis

1977 • 211 citations

Digoxin. A neurohormonal modulator in heart failure?

1991 • 194 citations

DOUBLE-BLIND PLACEBO-CONTROLLED COMPARISON OF DIGOXIN AND XAMOTEROL IN CHRONIC HEART FAILURE

1988 • 188 citations

Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure

1995 • 186 citations

Digitalis glycosides: mechanisms and manifestations of toxicity. Part I.

1984 • 186 citations

Milrinone, dobutamine, and nitroprusside: comparative effects on hemodynamics and myocardial energetics in patients with severe congestive heart failure.

1986 • 166 citations

Efficient estimation of the heart period power spectrum suitable for physiologic or pharmacologic studies

1990 • 146 citations

Are contraction and relaxation coupled in patients with and without congestive heart failure

1992 • 138 citations

Hemodynamic effects of intravenous digoxin in patients with severe heart failure initially treated with diuretics and vasodilators

1987 • 130 citations

Effects of Increasing Maintenance Dose of Digoxin on Left Ventricular Function and Neurohormones in Patients With Chronic Heart Failure Treated With Diuretics and Angiotensin-Converting Enzyme Inhibitors

1995 • 126 citations

Effect of Digitalis on Systolic Time Intervals in Heart Failure

1970 • 119 citations

Digitalis glycosides: Mechanisms and manifestations of toxicity

1984 • 113 citations

Comparison of echocardiography methods for assessment of left ventricular shortening and wall stress

1987 • 110 citations

Fractal dimension of heart rate time series: an effective measure of autonomic function

1993 • 104 citations

Relationship of Plasma Digitoxin and Digoxin to Cardiac Response Following Intravenous Digitalization in Man

1970 • 102 citations

The effect of deslanoside on the duration of the phases of ventricular systole in man

1965 • 84 citations

Estimation of heart rate power spectrum bands from real-world data: dealing with ectopic beats and noisy data

2003 • 84 citations

Dose-response relation between therapeutic levels of serum digoxin and systolic time intervals

1975 • 68 citations

Effects of Maintenance Digoxin Therapy on Systolic Time Intervals and Serum Digoxin Concentrations

1974 • 66 citations

Studies on digitalis. 13. A comparison of the effects of potassium on the inotropic and arrhythmia-producing actions of ouabain.

1966 • 60 citations

Improved left ventricular contractility with cool temperature hemodialysis

1992 • 58 citations

A concurrent audit of high digoxin plasma levels

1994 • 51 citations

Effect of Digoxin on Ejection Fraction in Elderly Patients with Congestive Heart Failure

1984 • 50 citations

Correlation of the electrical and mechanical changes in the dog heart during progressive digitalization.

1971 • 40 citations

Incidence of hospitalization for digitalis toxicity among elderly Americans

1994 • 39 citations

Progression of mild untreated heart failure purina six months follow-up and clinical and neurohumoral effects of ibopamine and digoxin as monotherapy

1995 • 32 citations

Plasma digitoxin levels and serial left ventricular ejection times after a digitalizing dose of digitoxin

1970 • 13 citations

Deleted Work

1955 • 0 citations