Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells

2004 • 689 citations

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

2002 • 633 citations

The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease

2002 • 598 citations

RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

1997 • 498 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

Antigen-driven effector CD8 T cell function regulated by T-bet

2003 • 413 citations

Inhibition of airway remodeling in IL-5–deficient mice

2004 • 374 citations

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

1995 • 364 citations

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

2004 • 327 citations

PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

2005 • 304 citations

Regulation of pulmonary fibrosis by chemokine receptor CXCR3

2004 • 294 citations

Dual Roles of IL-4 in Lung Injury and Fibrosis

2003 • 222 citations

A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)

1995 • 204 citations

Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis

2003 • 183 citations

Release of biologically active TGF-β1 by alveolar epithelial cells results in pulmonary fibrosis

2003 • 167 citations

Human Mesenchymal Stem Cells Maintain Transgene Expression during Expansion and Differentiation

2001 • 162 citations

Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury.

1994 • 161 citations

Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets

1996 • 156 citations

Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells

2003 • 155 citations

TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet

2005 • 154 citations

Cytokine profile and proteome analysis in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis

2005 • 147 citations

Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system

2001 • 141 citations

Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology.

1978 • 132 citations

Asbestosis and Idiopathic Pulmonary Fibrosis: Comparison of Thin-Section CT Features

2003 • 128 citations

Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

2006 • 119 citations

Role of Repeated Lung Injury and Genetic Background in Bleomycin-Induced Fibrosis

2003 • 117 citations

Idiopathic pulmonary fibrosis: new insights into pathogenesis

2004 • 110 citations

Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis

2003 • 106 citations

Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro

2004 • 101 citations

Lung infection with γ-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice

2005 • 98 citations

Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL‐induced apoptosis

2004 • 95 citations

Matrix Metalloproteinase-2 Status in Stromal Fibroblasts, Not in Tumor Cells, Is a Significant Prognostic Factor in Non–Small-Cell Lung Cancer

2004 • 94 citations

T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes

2004 • 93 citations

Essential role of T cell NF-kappa B activation in collagen-induced arthritis.

1999 • 87 citations

Asthmatic changes in mice lacking T-bet are mediated by IL-13

2005 • 81 citations

Immunoreactive interleukin 4 and interferon-? expression by type II alveolar epithelial cells in interstitial lung disease

1999 • 80 citations

Role of interferon-γ in the evolution of murine bleomycin lung fibrosis

2003 • 74 citations

Essential Role of T Cell NF-κB Activation in Collagen-Induced Arthritis

1999 • 69 citations

Direct effects of T‐bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation

2005 • 59 citations

Acute pulmonary toxicity of bleomycin: DNA scission and matrix protein mRNA levels in bleomycin-sensitive and -resistant strains of mice.

1989 • 57 citations

Interstitial lung diseases: characteristics at diagnosis and mortality risk assessment

2004 • 56 citations

Protective Immunity to Genital Herpes Simpex Virus Type 2 Infection Is Mediated by T-bet

2005 • 51 citations

Granulocyte Macrophage Colony–Stimulating Factor–Driven Respiratory Mucosal Sensitization Induces Th2 Differentiation and Function Independently of Interleukin-4

2002 • 46 citations

Smad3 Deficiency Ameliorates Experimental Obliterative Bronchiolitis in a Heterotopic Tracheal Transplantation Model

2004 • 41 citations

Idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis

2003 • 34 citations

T-bet and mucosal Th1 responses in the gastrointestinal tract

2002 • 32 citations

Development of a bleomycin hamster model of subchronic lung fibrosis

1992 • 31 citations

Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain

2003 • 16 citations

Betting on NKT and NK Cells

2004 • 15 citations

Bleomycin-induced DNA cleavage: studies in vitro and in intact cells.

1987 • 11 citations

T cells

1991 • 10 citations

Mechanisms of antifibrotic action of interferon gamma-1b in pulmonary fibrosis.

2000 • 9 citations