Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

2000 • 1,604 citations

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

1997 • 1,417 citations

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

2002 • 879 citations

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

2003 • 723 citations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

2003 • 712 citations

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

2002 • 701 citations

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

2003 • 662 citations

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

2003 • 646 citations

Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

2002 • 583 citations

Recombinant replication protein A: expression, complex formation, and functional characterization

1994 • 579 citations

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase

2002 • 574 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci

1998 • 539 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA.

1988 • 495 citations

AID Mediates Hypermutation by Deaminating Single Stranded DNA

2003 • 457 citations

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

2003 • 428 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

Cellular factors required for multiple stages of SV40 DNA replication in vitro.

1988 • 398 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts

2002 • 374 citations

Unraveling V(D)J Recombination

2004 • 359 citations

Replication of simian virus 40 origin-containing DNA in vitro with purified proteins.

1987 • 355 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

The generation of antibody diversity through somatic hypermutation and class switch recombination

2004 • 336 citations

AID mutant analyses indicate requirement for class-switch-specific cofactors

2003 • 314 citations

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

2003 • 269 citations

Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin

2003 • 269 citations

Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription

1998 • 265 citations

The Transcriptional Regulator RfaH Stimulates RNA Chain Synthesis after Recruitment to Elongation Complexes by the Exposed Nontemplate DNA Strand

2002 • 251 citations

Somatic Hypermutation of Immunoglobulin Genes

2002 • 235 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

Antisense intergenic transcription in V(D)J recombination

2004 • 220 citations

The influence of transcriptional orientation on endogenous switch region function

2003 • 208 citations

Transcription-induced Cleavage of Immunoglobulin Switch Regions by Nucleotide Excision Repair Nucleases in Vitro

2000 • 200 citations

DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine

2004 • 192 citations

Replication Protein A Confers Structure-specific Endonuclease Activities to the XPF-ERCC1 and XPG Subunits of Human DNA Repair Excision Nuclease

1996 • 187 citations

Somatic hypermutation of the AID transgene in B and non-B cells

2002 • 163 citations

Both DNA strands of antibody genes are hypermutation targets

1998 • 163 citations

A Sequence in the N-terminal Region of Human Uracil-DNA Glycosylase with Homology to XPA Interacts with the C-terminal Part of the 34-kDa Subunit of Replication Protein A

1997 • 146 citations

Monitoring and interpreting the intrinsic features of somatic hypermutation

1998 • 122 citations

Cis‐acting sequences that affect somatic hypermutation of Ig genes

1998 • 104 citations

Progress in understanding the mechanism and consequences of somatic hypermutation

1998 • 92 citations

Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism

2003 • 89 citations

Palindromic but not G-rich sequences are targets of class switch recombination

2001 • 84 citations

Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes

2002 • 79 citations

Immunoglobulin Genes: Generating Diversity with AID and UNG

2002 • 78 citations

The structural basis of the transition from initiation to elongation phases of transcription, as well as translocation and strand separation, by T7 RNA polymerase

2004 • 64 citations