Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: Immunohistochemical localization of an axonally transported plant lectin,Phaseolus vulgaris leucoagglutinin (PHA-L)

1984 • 1,205 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology

1986 • 944 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons

1991 • 584 citations

Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex

1981 • 538 citations

Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.

1992 • 521 citations

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

1991 • 500 citations

Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes

1992 • 412 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Spreading depression is not associated with neuronal injury in the normal brain

1988 • 365 citations

Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay

1996 • 334 citations

Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

1994 • 326 citations

Brain‐derived Neurotrophic Factor is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects them Against Glutamate‐induced Neurotoxicity

1993 • 287 citations

Spreading Depression Induces Tolerance of Cortical Neurons to Ischemia in Rat Brain

1995 • 266 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors

1994 • 210 citations

Cortical Spreading Depression Protects against Subsequent Focal Cerebral Ischemia in Rats

1996 • 169 citations

Spreading depression increases immunohistochemical staining of glial fibrillary acidic protein

1991 • 167 citations

Microglial Reaction in the Rat Cerebral Cortex Induced by Cortical Spreading Depression

1993 • 156 citations

Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex

1993 • 151 citations

The Role of Brain-derived Neurotrophic Factor in Transient Forebrain Ischemia in the Rat Brain

1994 • 115 citations

Local cerebral glucose utilization in thermally traumatized rat brain

1981 • 114 citations

Protective effect of spreading depression against neuronal damage following cardiac arrest cerebral ischaemia

1995 • 111 citations

Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity

1993 • 108 citations

Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid

1995 • 106 citations

Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for glial fibrillary acidic protein in cortex and hippocampus: inhibition by MK-801

1993 • 54 citations

Inhibition of Protein Synthesis During Repetitive Cortical Spreading Depression

1993 • 33 citations

Deleted Work

1955 • 0 citations