Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Common Principles of Protein Translocation Across Membranes

1996 • 1,081 citations

Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics

1999 • 928 citations

Proteomics: quantitative and physical mapping of cellular proteins

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Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

1995 • 859 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons

1991 • 584 citations

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

1995 • 558 citations

Heat‐shock proteins as molecular chaperones

1994 • 551 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Astrocytes protect neurons from hydrogen peroxide toxicity

1996 • 541 citations

Heat-shock response is associated with enhanced postischemic ventricular recovery.

1988 • 489 citations

Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression

1998 • 488 citations

Localization of 70-kDa stress protein induction in gerbil brain after ischemia

1988 • 465 citations

Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat

1996 • 456 citations

Role of glial cells in the regulation of the brain ion microenvironment

1989 • 448 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Antioxidant defense of the brain: a role for astrocytes

1997 • 400 citations

Cerebrovascular Disease: Pathophysiology, Diagnosis and Management

1998 • 386 citations

Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification

1991 • 382 citations

Heat-shock protein protection

1999 • 377 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

‘Ischemic tolerance’ phenomenon detected in various brain regions

1991 • 341 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

The role of apoptosis in sexual differentiation of the rat sexually dimorphic nucleus of the preoptic area

1996 • 321 citations

Stress Proteins and Tolerance to Focal Cerebral Ischemia

1996 • 298 citations

Spreading Depression Induces Tolerance of Cortical Neurons to Ischemia in Rat Brain

1995 • 266 citations

Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia

1992 • 247 citations

Trauma-Induced Protein in Rat Tissues: A Physiological Role for a "Heat Shock" Protein?

1981 • 233 citations

Induction of Ischemic Tolerance following Brief Focal Ischemia in Rat Brain

1994 • 223 citations

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

1997 • 214 citations

The temporal profile of 72-kDa heat-shock protein expression following global ischemia

1991 • 206 citations

Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain

1999 • 179 citations

JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: Basal expression and induction by spreading depression and epileptic seizures

1993 • 174 citations

Regional Expression of Heat Shock Protein-70 mRNA and c-Fos mRNA following Focal Ischemia in Rat Brain

1992 • 171 citations

Cortical Spreading Depression Protects against Subsequent Focal Cerebral Ischemia in Rats

1996 • 169 citations

Spreading depression increases immunohistochemical staining of glial fibrillary acidic protein

1991 • 167 citations

Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance

1994 • 161 citations

Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus

1993 • 155 citations

Hyperthermia-Induced Neuronal Protection against Ischemic Injury in Gerbils

1991 • 154 citations

Interleukin-1 Receptor and Receptor Antagonist Gene Expression After Focal Stroke in Rats

1997 • 148 citations

Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model

1993 • 146 citations

The stress gene response in brain.

1996 • 143 citations

Prior ischemic stress protects against experimental stroke

1993 • 139 citations

Genetic hypertension and increased susceptibility to cerebral ischemia

1992 • 135 citations

Heat Shock Protein hsp72 Induction in Cortical and Striatal Astrocytes and Neurons following Infarction

1991 • 135 citations

Induction of heat shock protein 72-like immunoreactivity in the hippocampal formation following transient global ischemia

1991 • 131 citations

Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

1986 • 129 citations

Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil

1993 • 128 citations

Astrocytes protect cultured neurons from degeneration induced by anoxia

1987 • 122 citations

Application of potassium chloride to the brain surface induces the c-fos proto-oncogene: reversal by MK-801

1990 • 118 citations

Neuron-specific enolase increases in cerebral and systemic circulation following focal ischemia

1993 • 116 citations

cDNA cloning and expression of stress‐inducible rat hsp70 normal and injured rat brain

1993 • 105 citations

Induction of ischemic tolerance and antioxidant activity by brief focal ischemia

1997 • 94 citations

Immunohistochemical localization of the low molecular weight stress protein HSP27 following focal cerebral ischemia in the rat

1995 • 90 citations

Expression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat

1996 • 85 citations

Astroglial and microglial reactions in the gerbil hippocampus with induced ischemic tolerance

1994 • 83 citations

Cortical Application of Potassium Chloride Induces the Low-Molecular Weight Heat Shock Protein (Hsp27) in Astrocytes

1997 • 81 citations

The inducible 70,000molecular weight heat shock protein is expressed in the degenerating dentate hilus and piriform cortex after systemic administration of kainic acid in the rat

1996 • 60 citations

Gene expression and induced ischemic tolerance following brief insults

1996 • 60 citations

Transient Neuronal Depolarization Induces Tolerance to Subsequent Forebrain Ischemia in Rats

1997 • 57 citations

Is glia disfunction the initial cause of neuronal death in ischemic penumbra?

1996 • 55 citations

Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for glial fibrillary acidic protein in cortex and hippocampus: inhibition by MK-801

1993 • 54 citations

Heat shock-induced myocardial protection against ischemic injury: a role for Hsp 70?

1996 • 51 citations

Differential expression of c-fos, Hsp70 and Hsp27 after photothrombotic injury in the rat brain

1997 • 40 citations

A comparison of induced heat-shock protein in neurons destined to survive and those destined to die after transient ischemia in rats

1993 • 37 citations

Use of Suppression Subtractive Hybridization Strategy for Discovery of Increased Tissue Inhibitor of Matrix Metalloproteinase-1 Gene Expression in Brain Ischemic Tolerance

1998 • 25 citations

The low molecular weight heat shock protein (hsp27) in rat Sertoli cells: evidence for identity of hsp27 with a germ cell-responsive phosphoprotein.

1992 • 21 citations

MK-801 affects the potassium-induced increase of glial fibrillary acidic protein immunoreactivity in rat brain

1992 • 19 citations

The role of extracellular ionic changes in upregulating the mRNA for glial fibrillary acidic protein following spreading depression

1995 • 17 citations