Troglitazone, a Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPARγ

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

1998 • 914 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

1997 • 655 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1998 • 599 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

Peroxisome proliterator-activated receptors, orphans with ligands and functions

1997 • 494 citations

Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade

2000 • 409 citations

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

2001 • 390 citations

Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer.

2000 • 382 citations

NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, Is Induced by Proliferative and Differentiative Stimuli

1996 • 353 citations

PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter

1998 • 334 citations

Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.

2001 • 304 citations

Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ

1998 • 281 citations

Peroxisome Proliferator‐activated Receptor γ Induces Growth Arrest and Differentiation Markers of Human Colon Cancer Cells

1999 • 263 citations

Oxidized Alkyl Phospholipids Are Specific, High Affinity Peroxisome Proliferator-activated Receptor γ Ligands and Agonists

2001 • 262 citations

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

1995 • 258 citations

Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation

1997 • 229 citations

Suppression of growth and transformation and induction of apoptosis by EGR-1.

1998 • 219 citations

Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells

2001 • 218 citations

Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53

2002 • 185 citations

Combinations of ERK and p38 MAPK Inhibitors Ablate Tumor Necrosis Factor-α (TNF-α) mRNA Induction

2001 • 174 citations

Early Growth Response-1-dependent Apoptosis Is Mediated by p53

1997 • 172 citations

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

1996 • 155 citations

Functional Characterization of a Non-AUUUA AU-Rich Element from the c-jun Proto-Oncogene mRNA: Evidence for a Novel Class of AU-Rich Elements

1996 • 154 citations

Adhesion-Dependent Regulation of an A+U-Rich Element-Binding Activity Associated with AUF1

1997 • 146 citations

Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain.

1995 • 145 citations

The Transcription Factor EGR-1 Directly Transactivates the Fibronectin Gene and Enhances Attachment of Human Glioblastoma Cell Line U251

2000 • 141 citations

Troglitazone Inhibits Growth of MCF-7 Breast Carcinoma Cells by Targeting G1 Cell Cycle Regulators

2001 • 140 citations

Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter

2001 • 136 citations

15-Deoxy-Δ12,14-prostaglandin J2 and Thiazolidinediones Activate the MEK/ERK Pathway through Phosphatidylinositol 3-Kinase in Vascular Smooth Muscle Cells

2001 • 132 citations

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.

1999 • 115 citations

Activation of peroxisome proliferator-activated receptor-γ stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells

2002 • 111 citations

Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells

2000 • 109 citations

Role of EGR-1 in Thapsigargin-Inducible Apoptosis in the Melanoma Cell Line A375-C6

1995 • 107 citations

Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-γ (PPARγ)-independent, antioxidant-related mechanism11Abbreviations: BADGE, bisphenol A diglycidyl ether; DCF, dichlorofluorescein; DCFH, 5- (and 6-)carboxy-2′,7′-dichlorodihydrofluorescein; PEPCK, phosphoenolpyruvate carboxykinase; 15-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2; PPAR, peroxisome proliferator-activated receptor; RPPO, ribosomal phosphoprotein PO; TZD…

2001 • 103 citations

15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor γ via the MAPK Signaling Pathway

2001 • 98 citations

Troglitazone Suppresses Cell Growth of Myeloid Leukemia Cell Lines by Induction of p21WAF1/CIP1 Cyclin-Dependent Kinase Inhibitor

1999 • 77 citations

Troglitazone Upregulates Nitric Oxide Synthesis in Vascular Smooth Muscle Cells

1999 • 72 citations

Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Mitogenic Induction of p21Cip1 by Modulating the Protein Kinase Cδ Pathway in Vascular Smooth Muscle Cells

2001 • 72 citations

Posttranscriptional Regulation of Cyclooxygenase-2 in Rat Intestinal Epithelial Cells

2000 • 69 citations

Physical interaction between p53 and primary response gene Egr-1

2001 • 60 citations

The Extracellular Signal-Regulated Protein Kinases Erk1/Erk2 Stimulate Expression and Biological Activity of the Transcriptional Regulator Egr-1

2001 • 60 citations

Effects of Troglitazone on Cellular Differentiation, Insulin Signaling, and Glucose Metabolism in Cultured Human Skeletal Muscle Cells

2001 • 57 citations

Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells.

1994 • 56 citations

Ligands of Peroxisome Proliferator-activated Receptor-γ Induce Apoptosis in AR42J Cells

2002 • 46 citations

Nitric oxide‐induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr‐1, a zinc finger transcription factor

2002 • 46 citations

Role of Egr-1 Gene Expression in B Cell Receptor-induced Apoptosis in an Immature B Cell Lymphoma

1997 • 37 citations

Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-γ, in caspase-dependent and -independent manners

2002 • 37 citations

Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway

2001 • 34 citations

Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells

2002 • 31 citations

Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2

2001 • 29 citations

Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-γ, in caspase-dependent and -independent manners

2002 • 21 citations

EGR-1, a UV-Inducible Gene in p53−/− Mouse Cells

2001 • 19 citations