Decline of hepatitis C virus load in serum during the first 24 h after administration of interferon-beta as a predictor of the efficacy of therapy

Classification of chronic hepatitis: Diagnosis, grading and staging

1994 • 2,506 citations

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

1998 • 2,112 citations

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region

1993 • 1,401 citations

Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources

1992 • 1,288 citations

Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection

1996 • 1,016 citations

Viral dynamics in hepatitis B virus infection.

1996 • 1,013 citations

Significance of serum hepatitis C virus RNA levels in chronic hepatitis C

1993 • 822 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region.

1990 • 548 citations

Hepatitis C Virus Type 1b (II) Infection in France and Italy

1995 • 490 citations

Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

1995 • 474 citations

Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa

1997 • 337 citations

The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients

1992 • 295 citations

Effect of interferon alfa on the dynamics of hepatitis C virus turnoverin vivo

1996 • 230 citations

Genotypic analysis of hepatitis C virus in American patients

1994 • 200 citations

Quantification of the initial decline of serum hepatitis c virus RNA and response to interferon alfa

1998 • 171 citations

Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferon-β

1993 • 149 citations

Influence of Viral Quasispecies on Effectiveness of Interferon Therapy in Chronic Hepatitis C Patients

1994 • 145 citations

Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

1994 • 141 citations

Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer

1994 • 140 citations

Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C

1998 • 137 citations

Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level

1995 • 135 citations

A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C

1993 • 131 citations

Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.

1994 • 121 citations

Viral and host factors that contribute to efficacy of interferon-α2a therapy in patients with chronic hepatitis C

1994 • 121 citations

Loss of serum HCV RNA at week 4 of interferon-α therapy is associated with more favorable long-term response in patients with chronic hepatitis C

1995 • 104 citations

High doses of recombinant α-interferon or γ-interferon for chronic hepatitis C: A randomized, controlled trial

1991 • 104 citations

Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy

1995 • 102 citations

Lack of benefit of escalating dosage of interferon alfa in patients with chronic hepatitis C

1995 • 102 citations

Ultrarapid hepatitis C virus clearance by daily high-dose interferon in non-responders to standard therapy

1998 • 79 citations

High doses of recombinant $alpha;-interferon or $gamma;-interferon for chronic hepatitis C: A randomized, controlled trial*1

1991 • 74 citations

Serial assay of hepatitis C virus RNA in serum for predicting response to interferon-α therapy

1995 • 68 citations

Characterization of simple and complex hepatitis C virus quasispecies by heteroduplex gel shift analysis: correlation with nucleotide sequencing

1995 • 68 citations

Hepatitis C virus genome complexity correlates with response to interferon therapy: A study in French patients with chronic hepatitis C

1997 • 67 citations

Dynamics of Hepatitis C Viremia following Interferon‐α Administration

1998 • 66 citations

Quasispecies nature of hepatitis C virus and response to alpha interferon: significance as a predictor of direct response to interferon

1997 • 62 citations

Early loss of serum hepatitis C virus RNA can predict a sustained response to interferon therapy in patients with chronic hepatitis C.

1997 • 57 citations

Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C

1995 • 53 citations

Immunohistochemical analysis of hepatic interferon alpha-beta receptor level: relationship between receptor expression and response to interferon therapy in patients with chronic hepatitis C

1999 • 41 citations

Expression of interferon alpha/beta receptor in the liver of chronic hepatitis C patients

1998 • 40 citations

Quantitative detection of hepatitis C virus RNA by multicyclic RT-PCR

1993 • 38 citations

Expression of Interferon Receptor Genes (IFNAR1 and IFNAR2 mRNA) in the Liver May Predict Outcome After Interferon Therapy in Patients With Chronic Genotype 2a or 2b Hepatitis C Virus Infection

1998 • 37 citations

IFN-alpha Receptor mRNA Expression in a United States Sample with Predominantly Genotype 1a/I Chronic Hepatitis C Liver Biopsies Correlates with Response to IFN Therapy

1999 • 36 citations

Quantitative analysis of interferon α/β receptor mRNA in the liver of patients with chronic hepatitis C: Correlation with serum hepatitis C virus‐RNA levels and response to treatment with interferon

1997 • 31 citations

Intravenous Recombinant Interferon-Beta versus Interferon-Alpha-2b and Ribavirin in Combination for Short-Term Treatment of Chronic Hepatitis C Patients Not Responding to Interferon-Alpha

1999 • 31 citations

Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level*1

1995 • 27 citations

Expression of interferon receptor genes in the liver as a predictor of interferon response in patients with chronic hepatitis C

1999 • 26 citations

Expression of interferon-alpha receptor mRNA in the liver in chronic liver diseases associated with hepatitis C virus: Relation to effectiveness of interferon therapy

1996 • 26 citations

Intravenous natural β-interferon in white patients with chronic hepatitis C who are nonresponders to α-interferon

1998 • 23 citations

Relationship between serum HCV markers and response to interferon therapy in chronic hepatitis C

1994 • 18 citations

Intravenous Natural β-Interferon in White Patients With Chronic Hepatitis C Who Are Nonresponders to α-Interferon

1998 • 14 citations

Viral kinetics can predict early response to alpha-interferon in chronic hepatitis C

1998 • 12 citations

Hepatitis C transmission between spouses

1996 • 6 citations