Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa

1989 • 1,658 citations

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region

1993 • 1,401 citations

Recombinant Interferon Alfa Therapy for Chronic Hepatitis C

1989 • 1,233 citations

Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease

1991 • 854 citations

Significance of serum hepatitis C virus RNA levels in chronic hepatitis C

1993 • 822 citations

Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay

1993 • 703 citations

Detection of hepatitis C virus by polymerase chain reaction and response to interferon-α therapy: Relationship to genotypes of hepatitis C virus

1992 • 689 citations

Factors predictive of response to interferon-α therapy in hepatitis C virus infection

1994 • 444 citations

Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy

1993 • 381 citations

Recombinant human α-interferon in patients with chronic non-A, non-B hepatitis: A multicenter randomized controlled trial from France

1991 • 320 citations

Comparison of 1 or 3 MU of interferon alfa-2b and placebo in patients with chronic non-A, non-B hepatitis

1991 • 253 citations

Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C

1994 • 234 citations

Hepatitis C viremia in chronic liver disease: Relationship to interferon-α or corticosteroid treatment

1994 • 215 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients.

1994 • 193 citations

Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis

1994 • 189 citations

Branched DNA amplification multimers for the sensitive, direct detection of human hepatitis viruses.

1991 • 170 citations

Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis

1994 • 166 citations

High sustained response rate and clearance of viremia in chronic hepatitis C after treatment with interferon-α2b for 60 weeks

1994 • 160 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: Definition of optimal conditions for specimen collection and clinical application in interferon-treated patients

1994 • 150 citations

Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferon-β

1993 • 149 citations

Influence of Viral Quasispecies on Effectiveness of Interferon Therapy in Chronic Hepatitis C Patients

1994 • 145 citations

Interferon-α for chronic hepatitis C: An analysis of pretreatment clinical predictors of response

1994 • 142 citations

Factors predictive of the response to interferon in patients with chronic hepatitis C

1994 • 91 citations

Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease

1994 • 87 citations

Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

1994 • 27 citations

Long-term response to higher doses of interferon (IFN) alfa-2b treatment of patients with chronic hepatitis C: A randomized multicenter trial

1993 • 21 citations

Helicobacter Pylori Infection and Peptic Ulcer Disease in Cameroon, West Africa

1994 • 19 citations

Differential pattern of sequence heterogeneity in the hepatitis C virus E1 and E2/NS1 proteins

1994 • 7 citations