Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

1996 • 669 citations

Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.

1992 • 465 citations

Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5' non-coding region

1995 • 419 citations

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

1995 • 344 citations

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

1995 • 322 citations

The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C.

1997 • 316 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV

1993 • 290 citations

Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients

1996 • 265 citations

Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

1995 • 264 citations

Accurate quantification of hepatitis C virus (HCV) RNA from all HCV genotypes by using branched-DNA technology

1996 • 227 citations

Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules

1995 • 216 citations

Distribution of Hepatitis C Virus Genotypes Determined by Line Probe Assay in Patients with Chronic Hepatitis C Seen at Tertiary Referral Centers in the United States

1996 • 197 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients.

1994 • 193 citations

Long-term follow-up of patients with chronic hepatitis C treated with different doses of interferon-alpha 2b.

1993 • 165 citations

Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection

1997 • 155 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: Definition of optimal conditions for specimen collection and clinical application in interferon-treated patients

1994 • 150 citations

T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti- hepatitis C virus?positive blood donors without viremi

1996 • 150 citations

Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection

1995 • 149 citations

Prediction of response to interferon treatment of chronic hepatitis C

1994 • 130 citations

Long-term follow-up of patients with chronic hepatitis C treated with different doses of interferon-α2b

1993 • 110 citations

Hepatitis C virus infection in kidney transplant recipients

1993 • 97 citations

Factors Affecting Treatment Responses to Interferon- in Chronic Hepatitis C

1996 • 96 citations

Implications of variations of "conserved" regions of hepatitis C virus genome

1995 • 94 citations

Lymphoproliferative responses to hepatitis C virus core, E1, E2, and NS3 in patients with chronic hepatitis C infection treated with interferon alfa

1996 • 73 citations

Collaboration of helper and cytotoxic T lymphocytes

1993 • 72 citations

Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients

1997 • 66 citations

Clinical predictors of response to recombinant interferon‐α treatment in patients with chronic non‐A, non‐B hepatitis (hepatitis C)

1994 • 46 citations

Characterization of the CD4+ and CD8+ tumor infiltrating lymphocytes propagated with bispecific monoclonal antibodies.

1989 • 34 citations

Hepatic HLA antigen display in chronic hepatitis B virus infection

1993 • 22 citations

A helper T‐cell antigen enhances generation of hepatitis C virus‐specific cytotoxic T lymphocytes in vitro

1995 • 22 citations

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