Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin

Methods in Enzymology , Vol

1966 • 26,261 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Membrane protein folding and oligomerization: the two-stage model

1990 • 927 citations

The hydrophobic moment detects periodicity in protein hydrophobicity.

1984 • 877 citations

Sequence Alignment of the G-Protein Coupled Receptor Superfamily

1992 • 847 citations

Projection structure of rhodopsin

1993 • 758 citations

Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors

1992 • 415 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

The SWISS-PROT protein sequence data bank

1991 • 341 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Hydrophobic Organization of Membrane Proteins

1989 • 316 citations

Structural Prediction of Membrane‐Bound Proteins

1982 • 285 citations

The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

1990 • 280 citations

Intrahelical hydrogen bonding of serine, threonine and cysteine residues within α-helices and its relevance to membrane-bound proteins

1984 • 242 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Molecular biology of 5-HT receptors

1989 • 214 citations

THE BACTERIAL PHOTOSYNTHETIC REACTION CENTER AS A MODEL FOR MEMBRANE PROTEINS

1989 • 204 citations

[25] Protein multiple sequence alignment and flexible pattern matching

1990 • 191 citations

Molecular evolution: computer analysis of protein and nucleic acid sequences.

1990 • 156 citations

Modeling α‐helical transmembrane domains: The calculation and use of substitution tables for lipid‐facing residues

1993 • 151 citations

Bacteriorhodopsin can be refolded from two independently stable transmembrane helixes and the complementary five-helix fragment

1992 • 139 citations

Three-dimensional modelling of G protein-linked receptors

1990 • 133 citations

The structure of bacteriorhodopsin and its relevance to the visual opsins and other seven-helix G-protein coupled receptors

1990 • 117 citations

The prediction of transmembrane protein sequences and their conformation: an evaluation

1990 • 113 citations

The ligand-binding domain of rhodopsin and other G protein-linked receptors

1992 • 107 citations

The role of turns in the structure of an α-helical protein

1993 • 101 citations

Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains

1992 • 98 citations

Distribution and complementarity of hydropathy in mutisunit proteins

1991 • 97 citations

The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols.

1987 • 87 citations

On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors.

1992 • 85 citations

Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands

1993 • 84 citations

Three-dimensional structure for the β2 adrenergic receptor protein based on computer modeling studies

1992 • 74 citations

Integral membrane protein structure: transmembrane α-helices as autonomous folding domains

1993 • 71 citations

An analysis of the periodicity of conserved residues in sequence alignments of G‐protein coupled receptors

1989 • 59 citations

[24] Identification of significant sequence patterns in proteins

1990 • 53 citations

Chapter 23. Structure and Function of G-Protein Coupled Receptors

1988 • 31 citations

Quadratic Minimization of Predictors for Protein Secondary Structure

1993 • 29 citations