Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

New Perspectives on a Subclinical Form of Visceral Leishmaniasis

1986 • 494 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

1985 • 321 citations

Metacyclogenesis in Leishmania promastigotes

1989 • 215 citations

T _H 1 and T _H 2 Cell Antigen Receptors in Experimental Leishmaniasis

1993 • 204 citations

Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to leishmania tropica

1981 • 199 citations

Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice.

1991 • 193 citations

Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.

1986 • 169 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction

1992 • 139 citations

Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.

1991 • 139 citations

Determinants of the immune response in visceral leishmaniasis: Evidence for predominance of endogenous interleukin 4 over interferon-γ production

1990 • 120 citations

Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.

1987 • 107 citations

Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis.

1992 • 104 citations

Immunoprotective Leishmania major synthetic T cell epitopes.

1990 • 100 citations

Interleukin‐4 transgenic mice of resistant background are susceptible to Leishmania major infection

1993 • 95 citations

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

1990 • 91 citations

IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.

1993 • 80 citations

Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis

1991 • 79 citations

Resistance to murine cutaneous leishmaniasis is mediated by T_H1 cells, but disease‐promoting CD4⁺ cells are different from T_H2 cells

1990 • 69 citations

A repetitive peptide of Leishmania can activate T helper type 2 cells and enhance disease progression.

1990 • 61 citations

Correlates of Leishmania-Specific Immunity in the Clinical Spectrum of Infection withLeishmania chagasi

1993 • 55 citations

Nonrandom use of J alpha gene segments. Influence of V alpha and J alpha gene location.

1991 • 54 citations

Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

1991 • 50 citations

Transfected Leishmania expressing biologically active IFN-gamma.

1993 • 44 citations

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