Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities 1 1Edited by G. Von Heijne

Basic local alignment search tool

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A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Escherichia coli and Salmonella :cellular and molecular biology

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Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria

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The Complete Genome Sequence of Escherichia coli K-12

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Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

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Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

The complete genome sequence of the Gram-positive bacterium Bacillus subtilis

1997 • 3,613 citations

The complete genome sequence of the gastric pathogen Helicobacter pylori

1997 • 3,529 citations

The Minimal Gene Complement of Mycoplasma genitalium

1995 • 2,499 citations

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. Strain PCC6803. II. Sequence Determination of the Entire Genome and Assignment of Potential Protein-coding Regions (Supplement)

1996 • 2,455 citations

Tmbase-A database of membrane spanning protein segments

1993 • 2,294 citations

Major Facilitator Superfamily

1998 • 2,232 citations

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. Strain PCC6803. II. Sequence Determination of the Entire Genome and Assignment of Potential Protein-coding Regions

1996 • 2,046 citations

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

Escherichia coli and Salmonella.

1996 • 1,585 citations

BACTERIAL HEAVY METAL RESISTANCE: New Surprises

1996 • 1,263 citations

Complete Sequence Analysis of the Genome of the Bacterium Mycoplasma Pneumoniae

1996 • 1,143 citations

Proton-dependent multidrug efflux systems

1996 • 1,062 citations

TopPred II: an improved software for membrane protein structure predictions

1994 • 954 citations

A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

1993 • 939 citations

A Model Recognition Approach to the Prediction of All-Helical Membrane Protein Structure and Topology

1994 • 790 citations

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

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Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria

1993 • 678 citations

ABC transporters: bacterial exporters

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Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

1992 • 585 citations

Ion efflux systems involved in bacterial metal resistances

1995 • 534 citations

Characterization of the ferrous iron uptake system of Escherichia coli

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A Novel Family of Ubiquitous Heavy Metal Ion Transport Proteins

1997 • 381 citations

Of urfs and orfs : a primer on how to analyze devised amino acid sequences

1986 • 370 citations

Genetic competence in Bacillus subtilis

1991 • 367 citations

Expression cloning of human and rat renal cortex Na/Pi cotransport.

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[23] Progressive alignment and phylogenetic tree construction of protein sequences

1990 • 350 citations

Functions of the gene products of Escherichia coli

1993 • 330 citations

Membrane transport proteins: implications of sequence comparisons

1992 • 330 citations

A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria

1994 • 320 citations

Phylogenetic Characterization of the MIP Family of Transmembrane Channel Proteins

1996 • 314 citations

Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.

1996 • 291 citations

The bacterial porin superfamily: sequence alignment and structure prediction

1991 • 268 citations

Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution

1994 • 263 citations

Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system

1992 • 259 citations

Evolution of ATP-binding cassette transporter genes

1995 • 249 citations

Conversion of Bacteriorhodopsin into a Chloride Ion Pump

1995 • 239 citations

Substrate Specificity and Expression Profile of Amino Acid Transporters (AAPs) in Arabidopsis

1995 • 235 citations

A new type of transporter with a new type of cellular function: <scp>l</scp>‐lysine export from Corynebacterium glutamicum

1996 • 233 citations

Primary sodium ion translocating enzymes

1997 • 229 citations

Holins: form and function in bacteriophage lysis

1995 • 228 citations

Nucleotide sequences of the Acinetobacter calcoaceticus benABC genes for benzoate 1,2-dioxygenase reveal evolutionary relationships among multicomponent oxygenases

1991 • 226 citations

EcoCyc: Encyclopedia of Escherichia coli genes and metabolism

1998 • 226 citations

A functional superfamily of sodium/solute symporters

1994 • 224 citations

Properties of voltage‐gated chloride channels of the ClC gene family.

1995 • 219 citations

Cation and sugar selectivity determinants in a novel family of transport proteins

1996 • 209 citations

Purification and Functional Reconstitution of the Recombinant Large Mechanosensitive Ion Channel (MscL) of Escherichia coli

1995 • 199 citations

The bacterial phosphotransferase system: new frontiers 30 years later

1994 • 197 citations

TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria

1997 • 189 citations

P-type ATPases of eukaryotes and bacteria: Sequence analyses and construction of phylogenetic trees

1994 • 177 citations

Insertion of proteins into bacterial membranes: mechanism, characteristics, and comparisons with the eucaryotic process

1989 • 167 citations

Colicins: structures, modes of action, transfer through membranes, and evolution

1994 • 166 citations

Homologous sugar transport proteins in Escherichia coli and their relatives in both prokaryotes and eukaryotes

1990 • 160 citations

Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane

1995 • 154 citations

Dual mode of energy coupling by the oxyanion-translocating ArsB protein

1995 • 152 citations

Expression cloning of rat renal Na+/SO4(2-) cotransport.

1993 • 151 citations

A potassium transporter of the yeast Schwanniomyces occidentalis homologous to the Kup system of Escherichia coli has a high concentrative capacity.

1995 • 150 citations

Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria

1997 • 150 citations

Secretion of amino acids by bacteria: Physiology and mechanism

1994 • 149 citations

Multidrug-Resistant Transport Proteins in Yeast: Complete Inventory and Phylogenetic Characterization of Yeast Open Reading Frames within the Major Facilitator Superfamily

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Translocations Through Natural Membranes

1967 • 144 citations

Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes — an analysis

1993 • 141 citations

Molecular Phylogeny as a Basis for the Classification of Transport Proteins from Bacteria, Archaea and Eukarya

1998 • 134 citations

Histidine-226 is part of the pH sensor of NhaA, a Na+/H+ antiporter in Escherichia coli.

1993 • 132 citations

Cloning, sequencing, and expression of the nhaB gene, encoding a Na+/H+ antiporter in Escherichia coli.

1992 • 131 citations

Yeast nutrient transporters

1997 • 118 citations

Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein

1993 • 115 citations

ACTIVE TRANSPORT IN ESCHERICHIA COLI: Passage to Permease

1986 • 107 citations

The first genome from the third domain of life

1997 • 107 citations

The metabolic pathway collection from EMP: the enzymes and metabolic pathways database

1996 • 106 citations

EcoCyc: an encyclopedia of Escherichia coli genes and metabolism

1996 • 100 citations

Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism

1996 • 100 citations

Proton-translocation phosphorylation in mitochondria, chloroplasts and bacteria: natural fuel cells and solar cells.

1967 • 99 citations

Structural features of the uniporter/symporter/antiporter superfamily

1995 • 97 citations

Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon

1990 • 90 citations

Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria

1993 • 83 citations

Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli

1996 • 80 citations

Identification of a residue in the translocation pathway of a membrane carrier

1993 • 78 citations

Isolation and nucleotide sequencing of lactose carrier mutants that transport maltose.

1985 • 76 citations

The Alcaligenes eutrophus protein HoxN mediates nickel transport in Escherichia coli

1995 • 75 citations

Amino acid neurotransmitter transporters: Structure, function, and molecular diversity

1993 • 74 citations

Residues in the pathway through a membrane transporter.

1995 • 74 citations

Cloning of the mgtE Mg2+ transporter from Providencia stuartii and the distribution of mgtE in gram-negative and gram-positive bacteria

1995 • 74 citations

Membrane Topology of the Melibiose Permease ofEscherichiacoliStudied bymelB−phoAFusion Analysis

1996 • 71 citations

Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system

1996 • 71 citations

Molecular cloning and sequencing of a gene from alkaliphilic Bacillus firmus OF4 that functionally complements an Escherichia coli strain carrying a deletion in the nhaA Na+/H+ antiporter gene.

1991 • 68 citations

Transport Processes in Eukaryotic and Prokaryotic Organisms

1996 • 67 citations

Molecular biology of the lactose carrier of Escherichia coli

1996 • 67 citations

Isolation and Characterization of Lactose Permease Mutants with an Enhanced Recognition of Maltose and Diminished Recognition of Cellobiose

1989 • 65 citations

Helix packing in polytopic membrane proteins: the lactose permease of Escherichia coli

1997 • 62 citations

Integrated Access to Metabolic and Genomic Data

1996 • 61 citations

Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases

1995 • 55 citations

Secondary transporters for citrate and the Mg(2+)-citrate complex in Bacillus subtilis are homologous proteins

1996 • 53 citations

Phylogenetic Approaches to the Identification and Characterization of Protein Families and Superfamilies

1996 • 47 citations

Computerized genetic map of Bacillus subtilis

1996 • 46 citations

Mapping, cloning, expression, and sequencing of the rhaT gene, which encodes a novel L-rhamnose-H+ transport protein in Salmonella typhimurium and Escherichia coli.

1992 • 46 citations

Sequencing and characterization of the sdaC gene and identification of the sdaCB operon in Escherichia coli K12

1994 • 41 citations

Microbes and membrane biology

1990 • 40 citations

Families and superfamilies of transport proteins common to prokaryotes and eukaryotes

1991 • 36 citations

Membrane topology analysis of Escherichia coli K-12 Mtr permease by alkaline phosphatase and beta-galactosidase fusions

1995 • 36 citations

Characterization of a novel transporter family that includes multiple Escherichia coli gluconate transporters and their homologues

2006 • 34 citations

Brucella abortus strain 2308 putative glucose and galactose transporter gene: cloning and characterization

1997 • 33 citations

Identification of valine 177 as a mutation altering specificity for transport of sugars by the Escherichia coli lactose carrier. Enhanced specificity for sucrose and maltose.

1990 • 33 citations

Life in mucus: sugar metabolism in Haemophilus influenzae

1996 • 31 citations

Novel Phosphotransferase System Genes Revealed by Bacterial Genome Analysis: The Complete Complement of pts Genes in Mycoplasma genitalium

1996 • 30 citations

Efflux Mechanisms of Resistance to Cadmium, Arsenic and Antimony in Prokaryotes and Eukaryotes

1997 • 28 citations

The molecular and cell biology of anion transport by bacteria

1992 • 26 citations

Phylogenetic analyses of the homologous transmembrane channel-forming proteins of the F0F1-ATPases of bacteria, chloroplasts and mitochondria

1996 • 26 citations

Novel Phosphotransferase System Genes Revealed by Bacterial Genome Analysis: Operons Encoding Homologues of Sugar-Specific Permease Domains of the Phosphotransferase System and Pentose Catabolic Enzymes

1996 • 25 citations

Characterization of the L-malate permease gene (maeP) of Streptococcus bovis ATCC 15352

1997 • 25 citations

Lactose permease mutants which transport (malto)-oligosaccharides

1993 • 25 citations

Isolation of Lactose Permease Mutants which Recognize Arabinose

1993 • 21 citations

A Synechococcus gene encoding a putative pore-forming intrinsic membrane protein

1995 • 15 citations

Nucleotide sequence of the Erwinia chrysanthemi gene encoding 2-keto-3-deoxygluconate permease

1989 • 14 citations

Structural and phylogenetic analysis of the MotA and MotB families of bacterial flagellar motor proteins

1996 • 12 citations

Proposed Topology of the Glucitol Permeases of Escherichia coli and Clostridium acetobutylicum

1996 • 11 citations

Phylogenetic characterization of the epithelial Na⁺channel (ENaC) family

1996 • 8 citations