A Pure Estrogen Antagonist Inhibits Cyclin E-Cdk2 Activity in MCF-7 Breast Cancer Cells and Induces Accumulation of p130-E2F4 Complexes Characteristic of Quiescence
Data up to Jan 2025
Total Citations Per Year
Abstract
References (57)
Antibodies, a laboratory manual
1989 • 12,929 citations
The nuclear receptor superfamily: The second decade
1995 • 6,929 citations
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 • 6,003 citations
Tamoxifen for early breast cancer: an overview of the randomised trials
1998 • 4,082 citations
The regulation of E2F by pRB-family proteins
1998 • 2,297 citations
Steroid hormone receptors: Many Actors in search of a plot
1995 • 1,854 citations
Nuclear Receptor Coregulators: Cellular and Molecular Biology*
1999 • 1,783 citations
A potent specific pure antiestrogen with clinical potential.
1991 • 1,111 citations
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes
1998 • 1,058 citations
Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1
1999 • 1,028 citations
D-type cyclins
1995 • 978 citations
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
1995 • 959 citations
Basic guide to the mechanisms of antiestrogen action.
1998 • 688 citations
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
1999 • 593 citations
Physicochemical properties of phospborothioate oligodeoxynucleotides
1988 • 567 citations
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.
1995 • 502 citations
Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1
1999 • 460 citations
Estrogen-induced Activation of Cdk4 and Cdk2 during G1-S Phase Progression Is Accompanied by Increased Cyclin D1 Expression and Decreased Cyclin-dependent Kinase Inhibitor Association with Cyclin E-Cdk2
1997 • 438 citations
The biology of cell reproduction
1985 • 403 citations
Growth Factors in Breast Cancer
1995 • 378 citations
The biology of cell reproduction
1985 • 375 citations
Comparison of the Effects of a Pure Steroidal antiestrogen With Those of Tamoxifen in a Model of Human Breast Cancer
1995 • 363 citations
Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element
1999 • 358 citations
Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
1995 • 351 citations
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.
1996 • 344 citations
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E
1999 • 340 citations
Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
1998 • 322 citations
Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.
1993 • 295 citations
Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer.
1994 • 289 citations
Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells.
1983 • 288 citations
Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution
1997 • 277 citations
c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry
1998 • 257 citations
Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells.
1996 • 233 citations
Down-regulation of p21 WAF1/CIP1 or p27 Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
2000 • 227 citations
The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G0 Cell State From a G1 Cell State
1996 • 222 citations
Oxford Textbook of Oncology
1996 • 197 citations
Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation.
1995 • 179 citations
The role of Cdk7 in CAK function, a retro-retrospective
1998 • 145 citations
Cdc6 protein causes premature entry into S phase in a mammalian cell-free system
1998 • 145 citations
Mechanisms of Cyclin-Dependent Kinase Inactivation by Progestins
1998 • 126 citations
Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-α in hematopoietic cell lines
1997 • 116 citations
Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells
1989 • 110 citations
Effects of tamoxifen on cell cycle progression of synchronous MCF-7 human mammary carcinoma cells.
1983 • 108 citations
Points of action of estrogen antagonists and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle.
1989 • 101 citations
Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line
1997 • 91 citations
Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth.
1998 • 87 citations
TGF-β1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression
1998 • 83 citations
Expression of the cyclin‐dependent kinase inhibitors p16INK4, p15INK4B and p21Waf1/cip1 in human breast cancer
1995 • 71 citations
Cooperation of p27Kip1 and p18INK4c in Progestin-Mediated Cell Cycle Arrest in T-47D Breast Cancer Cells
2000 • 69 citations
E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation
1999 • 66 citations
p130, p107, and pRb Are Differentially Regulated in Proliferating Cells and during Cell Cycle Arrest by α-Interferon
1998 • 52 citations
pRB, p107 and p130 as transcriptional regulators: Role in cell growth and differentiation
1997 • 40 citations
Progress in Cell Cycle Research
1996 • 34 citations
Acute effects of growth factors on T-47D breast cancer cell cycle progression
1993 • 30 citations
Anti-sense oligonucleotide of p21(waf1/cip1) prevents Interleukin 4-mediated elevation of p27(kip1) in low grade astrocytoma cells
2000 • 28 citations
Modulation of E2F Complexes during G0 to S Phase Transition in Human Primary B-lymphocytes
1999 • 27 citations
Granulocytic differentiation of myeloid progenitor cells by p130, the retinoblastoma tumor suppressor homologue
1999 • 16 citations