Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

Toll-like receptors and innate immunity

2001 • 4,138 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

The immunopathogenesis of sepsis

2002 • 2,686 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Immunotherapeutic uses of CpG oligodeoxynucleotides

2004 • 973 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

2004 • 731 citations

Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells

1999 • 633 citations

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

2005 • 625 citations

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

2005 • 616 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Epidermal Viral Immunity Induced by CD8α ⁺ Dendritic Cells But Not by Langerhans Cells

2003 • 580 citations

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α⁺ DC correlates with unresponsiveness to imidazoquinolines

2003 • 544 citations

Cutting Edge: Generation of Splenic CD8+ and CD8− Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures

2005 • 520 citations

Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

2004 • 500 citations

A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle

2004 • 478 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 • 440 citations

The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations

2000 • 418 citations

Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2

2003 • 390 citations

Mouse Plasmacytoid Cells

2002 • 377 citations

Most lymphoid organ dendritic cell types are phenotypically and functionally immature

2003 • 362 citations

A role for CD36 in the regulation of dendritic cell function

2001 • 315 citations

Cutting Edge: Conventional CD8α+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses

2004 • 298 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

T-cell control of Epstein–Barr virus-infected B cells is lost during P. falciparum malaria

1984 • 275 citations

Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation

2000 • 275 citations

Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway

2004 • 273 citations

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

2001 • 260 citations

Malaria Blood Stage Suppression of Liver Stage Immunity by Dendritic Cells

2003 • 240 citations

IMPAIRMENT OF THE IMMUNE RESPONSE TO VACCINATION AFTER ACUTE MALARIA

1978 • 210 citations

Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis

2003 • 203 citations

Development of a Novel Transgenic Mouse for the Study of Interactions Between CD4 and CD8 T Cells During Graft Rejection

2003 • 189 citations

Cutting Edge: Conventional CD8α+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1

2003 • 183 citations

Mini‐review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross‐priming and direct priming?

2003 • 181 citations

Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: Limitations of the Langerhans cells paradigm

2005 • 171 citations

Regulation of Antigen Presentation and Cross-Presentation in the Dendritic Cell Network: Facts, Hypothesis, and Immunological Implications

2005 • 170 citations

Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation

2004 • 164 citations

Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces

2005 • 164 citations

Characterization of two TCR transgenic mouse lines specific for herpes simplex virus

2002 • 148 citations

Control of cross‐presentation during dendritic cell maturation

2004 • 146 citations

Direct activation of dendritic cells by the malaria parasite,Plasmodium chabaudi chabaudi

2001 • 96 citations

Response of the Splenic Dendritic Cell Population to Malaria Infection

2004 • 86 citations

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming

2003 • 60 citations

Cross priming or direct priming: is that really the question?

2003 • 59 citations

Inhibition of T Cell Function During Malaria

2003 • 47 citations

Antigen-Presenting Cell Function duringPlasmodium yoeliiInfection

2002 • 40 citations