Regulation of the Mitochondrial Permeability Transition Pore by Ubiquinone Analogs. A Progress Report

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

1999 • 1,509 citations

Mitochondria and cell death

1999 • 763 citations

Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences

1979 • 727 citations

Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD+and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart

2001 • 658 citations

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

1998 • 546 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

A mitochondrial perspective on cell death

2001 • 430 citations

Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

1998 • 372 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

An Intrathecal Bolus of Cyclosporin a before Injury Preserves Mitochondrial Integrity and Attenuates Axonal Disruption in Traumatic Brain Injury

1999 • 268 citations

A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

1998 • 246 citations

Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury

1999 • 199 citations

Steady-State Kinetics of the Reduction of Coenzyme Q Analogs by Complex I (NADH:Ubiquinone Oxidoreductase) in Bovine Heart Mitochondria and Submitochondrial Particles

1996 • 156 citations

Three Classes of Ubiquinone Analogs Regulate the Mitochondrial Permeability Transition Pore through a Common Site

2000 • 148 citations

Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs.

1999 • 144 citations

Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia

1999 • 144 citations

Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia

1997 • 115 citations

Cyclosporin A and its nonimmunosuppressive analogue N‐Me‐Val‐4‐cyclosporin A mitigate glucose/oxygen deprivation‐induced damage to rat cultured hippocampal neurons

1999 • 113 citations

Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial

1990 • 108 citations

Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration

1992 • 98 citations

Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia

1999 • 61 citations

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment

1996 • 35 citations

Ubiquinone‐10 Protects Neurons from Virus‐Induced Degeneration

1994 • 26 citations

Ca²⁺‐reversible inhibition of the mitochondrial megachannel by ubiquinone analogues

2000 • 25 citations

Possible mechanism by which coenzyme Q10 improves reoxygenation-induced recovery of cardiac contractile force after hypoxia.

1987 • 21 citations