Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

Brain Corticosteroid Receptor Balance in Health and Disease*

1998 • 2,442 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

Brain Corticosteroid Receptor Balance in Health and Disease

1998 • 1,138 citations

Clinical and Biochemical Manifestations of Depression

1988 • 1,052 citations

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

1996 • 889 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression

1998 • 694 citations

The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders

1994 • 663 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions.

1996 • 547 citations

Clinical and Biochemical Manifestations of Depression

1988 • 528 citations

Bone Mineral Density in Women with Depression

1996 • 458 citations

Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

1993 • 440 citations

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

1994 • 394 citations

Ligand-independent Activation of the Glucocorticoid Receptor by β2-Adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells

1999 • 382 citations

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.

1993 • 335 citations

24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*

1987 • 315 citations

Loss of Glucocorticoid Fast Feedback in Depression

1991 • 297 citations

Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects

1996 • 275 citations

Mitogen-Activated and Cyclin-Dependent Protein Kinases Selectively and Differentially Modulate Transcriptional Enhancement by the Glucocorticoid Receptor

1997 • 271 citations

Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders

1993 • 258 citations

Antidepressants Increase Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Hippocampus in vivo

1992 • 255 citations

The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications

1992 • 238 citations

Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance

1997 • 235 citations

The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function¹

1999 • 226 citations

Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders

1998 • 210 citations

Effects of Cytokines on Glucocorticoid Receptor Expression And Function

1999 • 200 citations

Chronic Antidepressant Administration Alters the Subcellular Distribution of Cyclic AMP‐Dependent Protein Kinase in Rat Frontal Cortex

1989 • 196 citations

Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.

1990 • 190 citations

The Role of IL‐6 Type Cytokines and Their Receptors in Bonea^a

1998 • 182 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Hypothalamic-Pituitary-Adrenocortical Axis Changes in the Rat after Long-Term Treatment with the Reversible Monoamine Oxidase-A Inhibitor Moclobemide

1994 • 174 citations

Increased intra-abdominal fat deposition in patients with major depressive illness as measured by computed tomography

1997 • 169 citations

Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function

1995 • 168 citations

Low lumbar bone mineral density in patients with major depression

1994 • 167 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

Corticosterone regulation of Type I and Type II adrenal steroid receptors in brain, pituitary, and immune tissue

1991 • 157 citations

Evidence for Mineralocorticoid Receptor Facilitation of Glucocorticoid Receptor-Dependent Regulation of Hypothalamic-Pituitary-Adrenal Axis Activity*

1998 • 155 citations

Steroid-Independent Translocation of the Glucocorticoid Receptor by the Antidepressant Desipramine

1997 • 155 citations

Steroid-resistant asthma

1993 • 150 citations

Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain

1991 • 141 citations

Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: Implications for the dexamethasone suppression test

1992 • 139 citations

Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test

1985 • 135 citations

Glucocorticoid Receptors Are Differentially Expressed in the Cells and Tissues of the Immune System

1998 • 125 citations

Increased glucocorticoid receptor gene promoter activity after antidepressant treatment.

1992 • 114 citations

An Alternative Ligand-Independent Pathway for Activation of Steroid Receptors

1995 • 111 citations

Antidepressant drugs inhibit glucocorticoid receptor‐mediated gene transcription – a possible mechanism

2000 • 111 citations

Glucocorticoid receptors and depression.

1986 • 108 citations

Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone

1984 • 107 citations

Antidepressant drug action in a transgenic mouse model of the endocrine changes seen in depression.

1992 • 107 citations

cAMP-dependent protein kinase activity in major depression

1996 • 105 citations

Intracellular traffic of steroid hormone receptors

1996 • 96 citations

Long‐Term Treatment with Antidepressants Increases Glucocorticoid Receptor Binding and Gene Expression in Cultured Rat Hippocampal Neurones

1999 • 94 citations

Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor.

1992 • 89 citations

Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain

1988 • 79 citations

Differential effects of chronic antidepressant treatment on swim stress- and fluoxetine-induced secretion of corticosterone and progesterone.

1998 • 79 citations

Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content.

1995 • 78 citations

Modulation of glucocorticoid receptor function by protein kinase A

1992 • 74 citations

The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypotalamo-pituitary-adrenal axes

1991 • 74 citations

Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Increases Functional Coupling Between a G Protein (G_S) and Adenylyl Cyclase

1995 • 70 citations

Comparison of in vivo and in vitro glucocorticoid sensitivity in depression: Relationship to the dexamethasone suppression test

1988 • 70 citations

Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock.

1994 • 68 citations

Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant

1995 • 58 citations

Reduced G protein functions and immunoreactive levels in mononuclear leukocytes of patients with depression

1997 • 58 citations

The effect of long-term treatment with antidepressant drugs on the hippocampal mineralocorticoid and glucocorticoid receptors in rats

1993 • 57 citations

Glucocorticoid receptors in depression.

1995 • 52 citations

Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression

1993 • 49 citations

Reserpine-Induced Decrease in Type I and II Corticosteroid Receptors in Neuronal and Lymphoid Tissues of Adrenalectomized Rats

1990 • 49 citations

Differential autoregulation of glucocorticoid receptor expression in human T- and B-cell lines.

1993 • 48 citations

Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia

1985 • 41 citations

Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression

1991 • 40 citations

The relationship of the dexamethasone suppression test (1 mg and 2 mg) to basal plasma cortisol levels in endogenous depression

1987 • 40 citations

The effect of chronic treatment with antidepressant drugs on the corticosteroid receptor levels in the rat hippocampus.

1994 • 40 citations

Changes at multiple levels of the hypothalamo-pituitary adrenal axis following repeated electrically induced seizures

1990 • 39 citations

The effect of repeated combined treatment with nifedipine and antidepressant drugs or electroconvulsive shock on the hippocampal corticosteroid receptors in rats

1993 • 39 citations

Plasma sialyltransferase levels in psychiatric disorders as a possible indicator of HPA axis function

1997 • 38 citations

Pulse-Dosing and Conventional Application of Doxepin

1997 • 37 citations

Regulation of glucocorticoidreceptor-mRNA in human blood cells by amitriptyline and dexamethasone

1999 • 37 citations

Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone

1991 • 36 citations

Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease

1994 • 35 citations

Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.

1996 • 30 citations

Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder

1992 • 29 citations

The Glucocorticoid Insensitivity Syndrome

1996 • 27 citations

A whole-cell assay for glucocorticoid binding sites in normal human lymphocytes.

1985 • 24 citations

Decreased glucocorticoid receptor mRNA levels in individuals with depression, bipolar disorder and schizophrenia

2000 • 24 citations

Mononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression

1990 • 22 citations

Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome

1996 • 20 citations

Cortisol suppression per nanogram per milliliter of plasma dexamethasone in depressive and normal subjects

1988 • 20 citations

Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD).

1995 • 20 citations

Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA

1997 • 17 citations

Differential regulation by dexamethasone of glucocorticoid receptor messenger RNA concentrations in neuronal cultures derived from fetal rat hypothalamus and cerebral cortex

1990 • 16 citations

In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

1991 • 16 citations

Lymphocyte glucocorticoid receptor binding in depression: normal values following recovery

1988 • 16 citations

Lymphocyte glucocorticoid receptor binding during depression and after clinical recovery

1991 • 14 citations

Effects of Chronic Antidepressant Treatment on the Hypothalamic‐Pituitary‐Adrenal Axis of Wistar Rats

1994 • 14 citations

Glucocorticoid receptor binding in three different cell types in major depressive disorder: Lack of evidence op receptor binding defect

1992 • 12 citations