Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer

2004 • 3,606 citations

Integrative Genomic Profiling of Human Prostate Cancer

2010 • 3,485 citations

Targeting the phosphoinositide 3-kinase pathway in cancer

2009 • 2,512 citations

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

2006 • 2,463 citations

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

2009 • 2,168 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

2009 • 1,718 citations

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

2008 • 1,332 citations

The PI3K Pathway As Drug Target in Human Cancer

2010 • 1,190 citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

2004 • 951 citations

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

2011 • 921 citations

PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

2005 • 872 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

2008 • 757 citations

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

2009 • 741 citations

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

2009 • 678 citations

Pten Dose Dictates Cancer Progression in the Prostate

2003 • 665 citations

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

2006 • 596 citations

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1999 • 587 citations

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

2007 • 515 citations

The program of androgen-responsive genes in neoplastic prostate epithelium

2002 • 473 citations

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

2008 • 392 citations

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

2009 • 379 citations

HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability

2004 • 345 citations

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

2009 • 293 citations

Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

1999 • 289 citations

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

2010 • 248 citations

4–Year Follow–Up Results of a European Prospective Randomized Study on Neoadjuvant Hormonal Therapy prior to Radical Prostatectomy in T2–3N0M0 Prostate Cancer

2000 • 242 citations

The deficiency ofAkt1is sufficient to suppress tumor development inPten^+/−mice

2006 • 241 citations

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation

2007 • 240 citations

Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers

2003 • 187 citations

Murine Cell Lines Derived from Pten Null Prostate Cancer Show the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development

2007 • 165 citations

Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab

2009 • 123 citations

Regulation of Androgen Receptor Signaling by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Tumor Suppressor through Distinct Mechanisms in Prostate Cancer Cells

2004 • 120 citations

Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival

2008 • 101 citations

Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in Nkx3.1; Pten Mice

2006 • 85 citations

Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in aPten-Deficient Mouse Model of Prostate Cancer

2009 • 77 citations

Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

2009 • 75 citations

HER2が増幅されPI3K3CAが変異した乳癌細胞におけるPI3K/mTor二重阻害剤NVP‐BEZ235による特異的アポトーシス誘発

2009 • 60 citations

Multiple Oncogenic Pathway Signatures Show Coordinate Expression Patterns in Human Prostate Tumors

2008 • 46 citations

Predictive Value of PTEN and AR Coexpression of Sustained Responsiveness to Hormonal Therapy in Prostate Cancer—A Pilot Study

2008 • 42 citations

Commentary on Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

2009 • 26 citations

Hormone-Refractory prostate cancer

2002 • 24 citations

Pathological Effects of Prostate Cancer Correlate With Neuroendocrine Differentiation and PTEN Expression After Bicalutamide Monotherapy

2009 • 21 citations

Molecular and traditional chemotherapy: A united front against prostate cancer

2010 • 20 citations