Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in Nkx3.1; Pten Mice

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

The development of androgen-independent prostate cancer

2001 • 2,285 citations

The Influence of Finasteride on the Development of Prostate Cancer

2021 • 2,078 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Androgen Receptor in Prostate Cancer

2004 • 1,679 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

2003 • 1,073 citations

The Endocrinology and Developmental Biology of the Prostate*

1987 • 1,047 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

Roles for Nkx3.1 in prostate development and cancer

1999 • 660 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

1999 • 631 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence

2003 • 391 citations

Adaptation versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma.

1981 • 382 citations

Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.

2000 • 377 citations

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis

2002 • 320 citations

Chapter 2: The Role of Steroid Hormones in Prostate Carcinogenesis

2000 • 310 citations

Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

1999 • 289 citations

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

2002 • 242 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.

2003 • 229 citations

Hormones and prostate cancer: Current perspectives and future directions

2002 • 215 citations

Chromosomal deletions and tumor suppressor genes in prostate cancer.

2001 • 191 citations

The Adrenal Androgen Androstenediol Is Present in Prostate Cancer Tissue after Androgen Deprivation Therapy and Activates Mutated Androgen Receptor

2004 • 178 citations

PI3K/PTEN/Akt Pathway

2006 • 178 citations

PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling.

2003 • 174 citations

Prostatic Intraepithelial Neoplasia in Genetically Engineered Mice

2002 • 170 citations

Contribution of the androgen receptor to prostate cancer predisposition and progression.

2001 • 164 citations

Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.

1997 • 148 citations

Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis

2003 • 98 citations

Loss of PTEN is associated with progression to androgen independence

2006 • 79 citations

Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells

2006 • 24 citations

Effect of finasteride on risk of prostate cancer: How little we really know

2004 • 13 citations