Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

The Insulin Receptor: Molecular Biology and Transmembrane Signaling*

1987 • 285 citations

Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells.

1988 • 145 citations

Characterization of an endogenous substrate of the insulin receptor in cultured cells.

1987 • 136 citations

Participation of Ca currents in colonic electrical activity

1989 • 135 citations

Human Insulin-Receptor Gene: Partial Sequence and Amplification of Exons by Polymerase Chain Reaction

1990 • 115 citations

Mapping surface structures of the human insulin receptor with monoclonal antibodies: localization of main immunogenic regions to the receptor kinase domain

1986 • 81 citations

Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase

1989 • 76 citations

Conformational Changes in the α- and β-Subunits of the Insulin Receptor Identified by Anti-peptide Antibodies

1989 • 74 citations

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant

1991 • 67 citations

Substrates for Insulin-Receptor Kinase

1990 • 63 citations

Receptor cross-linking restores an insulin metabolic effect altered by mutation on tyrosine 1162 and tyrosine 1163

1989 • 49 citations

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.

1991 • 48 citations

Monoclonal Antibodies Mimic Insulin Activation of Ribosomal Protein S6 Kinase without Activation of Insulin Receptor Tyrosine Kinase

1989 • 47 citations

Insulin down-regulates insulin receptor number and up-regulates insulin receptor affinity in cells expressing a tyrosine kinase-defective insulin receptor.

1990 • 45 citations

Cascade of autophosphorylation in the β‐subunit of the insulin receptor

1989 • 43 citations

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected fibroblasts without activating receptor kinase

1989 • 16 citations