Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

Polygenic control of susceptibility to murine systemic lupus erythematosus

1994 • 484 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Lupus susceptibility loci in New Zealand mice.

1994 • 359 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Functional dissection of systemic lupus erythematosus using congenic mouse strains.

1997 • 268 citations

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.

1998 • 221 citations

B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.

1996 • 220 citations

The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development

2000 • 197 citations

Treatment of murine lupus with monoclonal anti-T cell antibody.

1985 • 186 citations

Genetic Dissection of Sle Pathogenesis:Sle3on Murine Chromosome 7 Impacts T Cell Activation, Differentiation, and Cell Death

1999 • 176 citations

Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

1999 • 176 citations

Functional consequences of engagement of the T cell receptor by low affinity ligands.

1993 • 171 citations

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.

1995 • 168 citations

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

1999 • 166 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

Murine lupus in the absence of alpha beta T cells.

1996 • 151 citations

Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.

1993 • 125 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.

1994 • 90 citations

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

1994 • 88 citations

Thymic Selection by a Single MHC/Peptide Ligand

1999 • 50 citations

Resting B cells from autoimmune lupus-prone New Zealand Black and (New Zealand Black x New Zealand White)F1 mice are hyper-responsive to T cell-derived stimuli.

1997 • 50 citations

Evidence for polyclonal T cell activation in murine models of systemic lupus erythematosus.

1994 • 47 citations

Aberrant cytokine expression and autocrine regulation characterize macrophages from young MRL+/+ and NZB/W F1 lupus-prone mice.

1997 • 47 citations

Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help.

1996 • 39 citations

Stability of Naive and Memory Phenotypes on Resting CD4 T Cells In Vivo

1999 • 37 citations

Central T Cell Tolerance in Lupus-Prone Mice: Influence of Autoimmune Background and the lpr Mutation

1998 • 35 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.

1996 • 27 citations