Subchronic administration of MK-801 in the rat decreases cortical binding of [3H]d-AP5, suggesting down-regulation of the corticalN-methyl-d-aspartate receptors

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

A practical computer-based approach to the analysis of radioligand binding experiments

1983 • 834 citations

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

1987 • 682 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

1986 • 543 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.

1980 • 398 citations

Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine

1987 • 380 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine.

1987 • 335 citations

New anticonvulsant drugs

1987 • 314 citations

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

1984 • 293 citations

Receptor Adaptations to Centrally Acting Drugs

1981 • 293 citations

Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain

1988 • 284 citations

Behavioral Pharmacology: The Current Status

1985 • 281 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

Classification and nomenclature of phencyclidine and sigma receptor sites

1987 • 272 citations

Excitatory amino acids in health and disease.

1988 • 254 citations

Light microscopic autoradiographic localisation of [3H]glycine and [3H]strychnine binding sites in rat brain

1986 • 247 citations

Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors.

1987 • 203 citations

Phencyclidine

1980 • 202 citations

Multiple opiate receptors: Emerging concepts

1981 • 201 citations

Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists

1986 • 182 citations

Quantitative autoradiography of [³H]‐MK‐801 binding sites in mammalian brain

1988 • 173 citations

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phophonovalerate (D-AP5) on rat cortical slices

1988 • 162 citations

Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat

1982 • 162 citations

Glycine modulates [3H]MK-801 binding to the NMDA receptor in rat brain

1987 • 160 citations

Binding Characteristics and Interactions of Depressant Drugs with [³⁵S]t-Butylbicyclophosphorothionate, a Ligand that Binds to the Picrotoxinin Site

1984 • 156 citations

MK-801 powerfully protects against N-methyl aspartate neurotoxicity

1987 • 141 citations

Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel

1987 • 140 citations

Adaptive changes in catecholamine receptors in the central nervous system

1981 • 120 citations

Receptor alterations and drug tolerance

1979 • 117 citations

Kinetic characterization of the phencyclidine-N-methyl-D-aspartate receptor interaction: evidence for a steric blockade of the channel

1988 • 112 citations

Glycine potentiates [3H]TCP binding to rat cortical membranes

1987 • 105 citations

Rat Brain N -Methyl-D-Aspartate Receptors Expressed in Xenopus oocytes

1987 • 104 citations

Evidence for an endogenous peptide ligand for the phencyclidine receptor

1984 • 102 citations

Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands

1988 • 99 citations

Quantitative autoradiographic localization of NMDA receptors in rat brain using [3H]CPP: comparison with [3H]TCP binding sites

1987 • 88 citations

Phencyclidine-like discriminative stimulus properties of MK-801 in rats

1988 • 82 citations

Effect of chronic treatment of ethanol on benzodiazepine and picrotoxin sites on the GABA receptor complex in regions of the brain of the rat

1986 • 75 citations

Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

1988 • 71 citations

Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine

1987 • 70 citations

Glycine modulation of the phencyclidine binding site in mammalian brain

1988 • 63 citations

Behavioral effects of chronic phencyclidine administration in rats

1982 • 60 citations

[3H]D-2-amino-5-phosphonopentanoate as a ligand for N-methyl-d-aspartate receptors in the mammalian central nervous system

1988 • 56 citations

The effects of phencyclidine on operant behavior in the rat: Biphasic effect and tolerance development

1978 • 49 citations

Chronic phencyclidine treatment decreases phencyclidine and dopamine receptors in rat brain

1982 • 46 citations

Chronic administration of the GABA-transaminase inhibitor ethanolamine O-sulphate leads to up-regulation of GABA binding sites

1984 • 35 citations

An endogenous ligand of the brain σ/PCP receptor antagonizes NMDA-induced neurotransmitter release

1987 • 34 citations

The simultaneous determination of 3,4-dihydroxyphenylethylene glycol, 3,4-dihydroxyphenylacetic acid and catecholamines in brain tissue by high performance liquid chromatography with electrochemical detection

1983 • 33 citations

Actions of phencyclidine on rat locus coeruleus neurones in vitro

1986 • 33 citations

Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum

1982 • 26 citations

Continuous intravenous infusion of phencyclidine in unrestrained rats results in the rapid induction of tolerance and physical dependence.

1985 • 25 citations

Effects of phencyclidine on rat prolactin dopamine receptor and locomotor activity

1983 • 23 citations

3,4‐DIHYDROXYPHENYLACETIC ACID (DOPAC) AND THE RAT MESOLIMBIC DOPAMINERGIC PATHWAY: DRUG EFFECTS AND EVIDENCE FOR SOMATODENDRITIC MECHANISMS

1980 • 23 citations

Effects of the NMDA receptor antagonist MK-801 against amygdaloid-kindled seizures in the rat

1989 • 16 citations

Quantitative conformational analyses predict distinct receptor sites for PCP-like and σ drugs

1987 • 12 citations

Subchronic administration of GABAergic agonists elevates [3H]GABA binding and produces tolerance in striatal dopamine catabolism

1985 • 12 citations

Isolation and identification of an endogenous ligand for the phencyclidine receptor.

1986 • 11 citations

Effects of chronic phencyclidine administration on the schedule-controlled behavior of rats.

1983 • 9 citations

Modulating glutamate pharmacology

1987 • 6 citations

[3H]spiperone binding in the rat striatum during the development of physical dependence on phencyclidine and after withdrawal

1985 • 4 citations

COMPARISON OF THE PROPERTIES OF [³H]‐<scp>d</scp>‐2‐AMINO‐5‐PHOSPHONOPENTANOIC ACID AND [³H]‐<scp>dl</scp>‐2‐AMINO‐7‐PHOSPHONOHEPTANOIC ACID BINDING TO HOMOGENATES OF RAT CEREBRAL CORTEX

1989 • 4 citations

Effects of phencyclidine on active avoidance and escape in rats

1985 • 3 citations