Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

1999 • 2,478 citations

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 • 1,993 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid¹

1998 • 1,562 citations

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly∗∗Access the “Journal Club” discussion of this paper at http:/www.elsevier.com/locate/ajmselect/

1999 • 1,467 citations

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

1994 • 1,302 citations

Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study

1996 • 1,106 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid

1998 • 1,009 citations

Adipose tissue as an endocrine and paracrine organ

1998 • 1,000 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation.

1997 • 756 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in Vivo

1997 • 677 citations

Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

1995 • 609 citations

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.

1993 • 555 citations

Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.

1993 • 488 citations

Social inequality in coronary risk: Central obesity and the metabolic syndrome. Evidence from the Whitehall II study

1997 • 434 citations

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

1991 • 413 citations

Inflammatory Cytokines Impair Endothelium-Dependent Dilatation in Human Veins In Vivo

1997 • 405 citations

Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

1994 • 387 citations

Cytokines Regulate Vascular Functions Related to Stability of the Atherosclerotic Plaque

1995 • 374 citations

Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immunocytochemical stain.

1993 • 348 citations

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1994 • 343 citations

Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?

1997 • 309 citations

Effects of endotoxin and cytokines on lipid metabolism

1994 • 308 citations

Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.

1996 • 301 citations

α, β, γ, and δ T Cell Antigen Receptor Genes Arose Early in Vertebrate Phylogeny

1997 • 285 citations

Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia.

1992 • 283 citations

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans

1993 • 241 citations

Cigarette Smoking Influences Cytokine Production and Antioxidant Defences

1995 • 222 citations

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

1995 • 220 citations

Aromatase activity and interleukin-6 production by normal and malignant breast tissues.

1995 • 193 citations

Effect of endotoxin in IL-1 beta-deficient mice.

1996 • 190 citations

Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary- adrenal axis

1993 • 156 citations

GM-CSF, IL-1α, IL-β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1α and TNF-α

1994 • 150 citations

Interleukin 1? and interleukin 6, but not tumor necrosis factor ?, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes

1998 • 135 citations

A Healthy Body in a Healthy Mind--and Vice Versa--The Damaging Power of "Uncontrollable" Stress

1998 • 125 citations

Oligomerization of Endothelial Nitric Oxide Synthase

1995 • 115 citations

Aromatase activity and interleukin-6 production by normal and malignant breast tissues

1995 • 79 citations

Expression of inflammatory mediators and adhesion molecules in human atherosclerotic plaque

1997 • 71 citations

Effects of lnterleukin-1 and Tumor Necrosis Factor on Megakaryocytopoiesis: Mechanism of Reactive Thrombocytosis

1995 • 58 citations