E2A Basic-Helix-Loop-Helix Transcription Factors are Negatively Regulated by Serum Growth Factors and by the Id3 Protein

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1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

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1987 • 888 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

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1992 • 531 citations

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1994 • 420 citations

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The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein.

1994 • 371 citations

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1989 • 363 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

1990 • 347 citations

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

1990 • 330 citations

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

1994 • 323 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

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1992 • 280 citations

The expression pattern ofId4, a novel dominant negative helix-loop-helix protein, is distinct fromId1,1d2andId3

1994 • 274 citations

Inhibition of Myeloid Differentiation by the Helix-Loop-Helix Protein Id

1992 • 267 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.

1991 • 240 citations

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

1992 • 234 citations

Id proteins control growth induction in mammalian cells.

1994 • 229 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

Cell proliferation inhibited by MyoD1 independently of myogenic differentiation

1990 • 224 citations

Oncogenic conversion by regulatory changes in transcription factors

1991 • 215 citations

MyoD induces growth arrest independent of differentiation in normal and transformed cells.

1990 • 203 citations

Regulation of G1 progression by E2A and Id helix-loop-helix proteins.

1994 • 199 citations

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

1993 • 196 citations

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

1993 • 173 citations

Id Proteins Id1 and Id2 Selectively Inhibit DNA Binding by One Class of Helix-Loop-Helix Proteins

1991 • 165 citations

Preferred Sequences for DNA Recognition by the TAL1 Helix-Loop-Helix Proteins

1994 • 164 citations

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1992 • 152 citations

Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

1991 • 151 citations

Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

1991 • 150 citations

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

1991 • 123 citations

The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors

1992 • 115 citations

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1990 • 112 citations

Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

1992 • 109 citations

Neuronal Expression of Regulatory Helix-Loop-Helix Factor Id2 Gene in Mouse

1993 • 105 citations

Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.

1993 • 103 citations

An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

1993 • 98 citations

Myocardial activation of the human cardiac alpha-actin promoter by helix-loop-helix proteins.

1992 • 96 citations

The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity.

1993 • 91 citations

A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene

1990 • 91 citations

HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors

1992 • 86 citations

Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins.

1994 • 85 citations

Expression of the Helix-Loop-Helix Factor Id during Mouse Embryonic Development

1993 • 82 citations

The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells.

1994 • 77 citations

Detection and modulation in vivo of helix-loop-helix protein-protein interactions.

1993 • 73 citations

A Heterodimer of HEB and an E12-Related Protein Interacts with the CD4 Enhancer and Regulates Its Activity in T-Cell Lines

1993 • 71 citations

Id expression during mouse development: A role in morphogenesis

1992 • 63 citations

Activation of Helix-Loop-Helix Proteins Id1, Id2 and Id3 during Neural Differentiation

1994 • 58 citations

Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning.

1992 • 54 citations

Structural organisation and chromosomal mapping of the human Id-3 gene

1994 • 47 citations

Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization.

1994 • 45 citations

Repression of Immunoglobulin Enhancers by the Helix-Loop-Helix Protein Id: Implications for B-Lymphoid-Cell Development

1991 • 43 citations

Functional Characterization of the Developmentally Controlled Immunoglobulin Kappa 3′ Enhancer: Regulation by Id, a Repressor of Helix-Loop-Helix Transcription Factors

1991 • 40 citations

Expression of ID, a negative regulator of helix-loop-helix DNA binding proteins, is down-regulated at confluence and enhanced by dexamethasone in a mouse osteoblastic cell line, MC3T3E1

1991 • 38 citations

Pancreatic β-Cell-Type-Specific Transcription of the Insulin Gene Is Mediated by Basic Helix-Loop-Helix DNA-Binding Proteins

1991 • 37 citations

Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture.

1994 • 36 citations

Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor

1990 • 28 citations

Activation of muscle-specific transcription by myogenic helix-loop-helix proteins.

1992 • 25 citations

The Loop Region of the Helix-Loop-Helix Protein Id1 Is Critical for Its Dominant Negative Activity

1993 • 23 citations

Murine Helix-Loop-Helix Transcriptional Activator Proteins Binding to the E-Box Motif of the Akv Murine Leukemia Virus Enhancer Identified by cDNA Cloning

1992 • 20 citations

Class A basic Helix-Loop-Helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy

1994 • 4 citations