Regulation of G1 progression by E2A and Id helix-loop-helix proteins.

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis

1978 • 491 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins.

1992 • 480 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex

1988 • 442 citations

Interplay between proliferation and differentiation within the myogenic lineage

1992 • 424 citations

HLH proteins, fly neurogenesis, and vertebrate myogenesis

1993 • 420 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins

1990 • 407 citations

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein

1990 • 387 citations

Reversal of Terminal Differentiation Mediated by p107 in Rb ^-/- Muscle Cells

1994 • 369 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Making muscle in mammals

1992 • 292 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

Inhibition of Myeloid Differentiation by the Helix-Loop-Helix Protein Id

1992 • 267 citations

Binding and Suppression of the Myc Transcriptional Activation Domain by p107

1994 • 242 citations

Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila.

1991 • 238 citations

Id proteins control growth induction in mammalian cells.

1994 • 229 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

Cell proliferation inhibited by MyoD1 independently of myogenic differentiation

1990 • 224 citations

MyoD induces growth arrest independent of differentiation in normal and transformed cells.

1990 • 203 citations

Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs.

1990 • 199 citations

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

1993 • 196 citations

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins.

1993 • 172 citations

Id Proteins Id1 and Id2 Selectively Inhibit DNA Binding by One Class of Helix-Loop-Helix Proteins

1991 • 165 citations

B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits

1991 • 164 citations

A New Transcriptional-Activation Motif Restricted to a Class of Helix-Loop-Helix Proteins Is Functionally Conserved in Both Yeast and Mammalian Cells

1993 • 158 citations

HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id

1993 • 157 citations

Enhancer-Binding Activity of the tal-1 Oncoprotein in Association with the E47/E12 Helix-Loop-Helix Proteins

1991 • 156 citations

An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

1990 • 153 citations

DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer.

1992 • 152 citations

Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

1991 • 151 citations

Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer

1991 • 150 citations

Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

1991 • 150 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

1992 • 139 citations

A human Id-like helix-loop-helix protein expressed during early development.

1992 • 138 citations

Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia.

1993 • 138 citations

The E2A gene product contains two separable and functionally distinct transcription activation domains.

1993 • 138 citations

Myogenesis and developmental control genes

1990 • 121 citations

Skeletal myogenesis: genetics and embryology to the fore

1993 • 103 citations

An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

1993 • 98 citations

Performance of an automated system for capillary microinjection into living cells

1988 • 98 citations

HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors

1992 • 86 citations

Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.

1991 • 81 citations

Single cell assay with an automated capillary microinjection system

1988 • 67 citations

Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis.

1992 • 64 citations

Repression of Immunoglobulin Enhancers by the Helix-Loop-Helix Protein Id: Implications for B-Lymphoid-Cell Development

1991 • 43 citations

Helix-loop-helix genes translocated in lymphoid leukemia

1991 • 41 citations

Pancreatic β-Cell-Type-Specific Transcription of the Insulin Gene Is Mediated by Basic Helix-Loop-Helix DNA-Binding Proteins

1991 • 37 citations

Fate of exogenous recombinant plasmids introduced into mouse and human cells

1985 • 37 citations

achaete-scute feminizing activities and Drosophila sex determination

1993 • 36 citations

Inefficient Homooligomerization Contributes to the Dependence of Myogenin on E2A Products for Efficient DNA Binding

1991 • 24 citations

Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene

1993 • 22 citations

Single cell assay with an automated capillary microinjection system

1991 • 10 citations