Intracellular Acidification Triggered by Mitochondrial-derived Hydrogen Peroxide Is an Effector Mechanism for Drug-induced Apoptosis in Tumor Cells

Mitochondria and Apoptosis

1998 • 8,909 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Respiratory burst in human neutrophils

1999 • 801 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

1999 • 495 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death

1997 • 411 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Lucigenin chemiluminescence in the assessment of neutrophil superoxide production

1987 • 354 citations

Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases

1997 • 316 citations

Intracellular Alkalinization Suppresses Lovastatin-induced Apoptosis in HL-60 Cells through the Inactivation of a pH-dependent Endonuclease

1995 • 306 citations

2,7‐Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation

1997 • 285 citations

Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs

1998 • 271 citations

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

1998 • 254 citations

Superoxide anion is a natural inhibitor of FAS-mediated cell death.

1996 • 241 citations

Analysis of the membrane potential of rat‐ and mouse‐liver mitochondria by flow cytometry and possible applications

1990 • 241 citations

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.

1996 • 214 citations

Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu

1998 • 205 citations

Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells

1993 • 194 citations

An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis

1999 • 192 citations

Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition

1997 • 179 citations

Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents

1996 • 171 citations

Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation

1999 • 170 citations

Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

1998 • 158 citations

Caspases disrupt mitochondrial membrane barrier function

1998 • 137 citations

Depletion of cellular ATP inhibits Na+/H+ antiport in cultured human cells. Modulation of the regulatory effect of intracellular protons on the antiporter activity.

1986 • 119 citations

Intracellular acidification induces apoptosis by stimulating ICE-like protease activity

1997 • 118 citations

Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis

2000 • 116 citations

Doxorubicin‐induced apoptosis in human T‐cell leukemia is mediated by caspase‐3 activation in a Fas‐independent way

1997 • 114 citations

Events in Apoptosis

1996 • 109 citations

ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization.

1994 • 107 citations

Detection of pro‐caspase‐3 in cytosol and mitochondria of various tissues

1998 • 94 citations

Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification

1998 • 82 citations

Mechanism of Hydrogen Peroxide and Hydroxyl Free Radical–Induced Intracellular Acidification in Cultured Rat Cardiac Myoblasts

1996 • 76 citations

Caspase Activation in MCF7 Cells Responding to Etoposide Treatment

1998 • 70 citations

Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells.

1996 • 57 citations

Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells

2000 • 55 citations

Vanadate induces apoptosis in epidermal JB6 P+ cells via hydrogen peroxide-mediated reactions.

1999 • 52 citations

Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells

2000 • 52 citations

Purified Photoproducts of Merocyanine 540 Trigger Cytochrome C Release and Caspase 8-Dependent Apoptosis in Human Leukemia and Melanoma Cells

1999 • 48 citations

Mitochondria generate superoxide anion radicals and hydrogen peroxide

1997 • 47 citations

Perturbation of Cell pH Regulation by H2O2 in Renal Epithelial Cells

1993 • 40 citations

Activation of a low pH-dependent nuclease by apoptotic agents

1999 • 39 citations

Hydrogen Peroxide Decreases pH_iin Human Aortic Endothelial Cells by Inhibiting Na⁺/H⁺Exchange

1998 • 38 citations

Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells

1997 • 35 citations

The use of diphenylene iodonium, an inhibitor of NADPH oxidase, to investigate the antimicrobial action of human monocyte derived macrophages

1990 • 33 citations

Vincristine- and cisplatin-induced apoptosis in human retinoblastoma. Potentiation by sodium butyrate

1998 • 27 citations

Chapter 6 Measurement of Intracellular pH

1990 • 25 citations

Caspase proteases mediate apoptosis induced by anticancer agent preactivated MC540 in human tumor cell lines

1998 • 23 citations

Two Distinct Modes of Oncoprotein Expression During Apoptosis Resistance in Vincristine and Daunorubicin Multidrug-Resistant HL60 Cells

1999 • 13 citations

Early Cytoplasmic Acidification in Retinamide-Mediated Apoptosis of Human Promyelocytic Leukemia Cells

1996 • 10 citations

Relationship of mitochondrial function and cellular adenosine triphosphate levels to pMC540 and merodantoin cytotoxicity in MCF-7 human breast cancer cells

1995 • 7 citations

INHIBITION OF RAT GLOMERULAR MESANGIAL CELL SODIUM/HYDROGEN EXCHANGE BY HYDROGEN PEROXIDE

1995 • 6 citations